408318-36-5Relevant academic research and scientific papers
Synthesis of β-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones
Yang, Shyh-Ming,Kuo, Gee-Hong,Gaul, Michael D.,Murray, William V.
, p. 3464 - 3469 (2016/05/19)
Phosphonium salt-activated, Pd-catalyzed Suzuki-Miyaura and Sonogashira cross-coupling reactions of cyclic 1,3-diones in the synthesis of β-substituted cyclic enones are described. These transformations exhibit good isolated yield and high generality with respect to both substrates and coupling partners. Extension of the substrate scope to cyclic 1,3-dione equivalents, such as 2-cyanocyclohexanone (4), is also briefly examined.
Cyclic alkenenitriles: Chemoselective oxonitrile cyclizations
Fleming, Fraser F.,Funk, Lee A.,Altundas, Ramazan,Sharief, Vaqar
, p. 9414 - 9416 (2007/10/03)
Potassium tert-butoxide triggers the chemoselective cyclization between nitrile anions and remote, enolizable carbonyl groups, despite the acidity difference favoring enolate formation and addition to the nitrile group. Domino deprotonation, cyclization,
