408347-40-0

Basic information

• Product Name: (3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-Trimethyl-10-(trifluoromethyl)perhydro-3,12-epoxypyrano[4,3-j]-1,2-benzodioxepine
• Synonyms: 10-Deoxo-10(R)-(trifluoromethyl)artemisin
• CAS NO: 408347-40-0
• Molecular Formula: C₁₆H₂₃F₃O₄
• Molecular Weight: 336.35451
• Mol File: 408347-40-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-Trimethyl-10-(trifluoromethyl)perhydro-3,12-epoxypyrano[4,3-j]-1,2-benzodioxepine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-Trimethyl-10-(trifluoromethyl)perhydro-3,12-epoxypyrano[4,3-j]-1,2-benzodioxepine(408347-40-0)
• EPA Substance Registry System: (3R,5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-Trimethyl-10-(trifluoromethyl)perhydro-3,12-epoxypyrano[4,3-j]-1,2-benzodioxepine(408347-40-0)

Safety Data

• Hazardous Substances Data: 408347-40-0(Hazardous Substances Data)

Upstream product

• 185418-56-8 (1S,4R,5R,8R,9R,10R,12R,13R)-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.0^4,13.0^8,13]hexadecan-10-ol 
• 408347-42-2 10-bromo-1,5,9-trimethyl-10-(trifluoromethyl)-11,14,15,16-tetraoxatetracyclo[10.3.1.0^4,13.0^8,13]hexadecane 

Relevant articles and documents

First synthesis of 10α-(trifluoromethyl)deoxoartemisinin

(equation presented) A novel, nonacetal (trifluoromethyl)deoxoartemisinin was prepared with good stereoselectivity. This compound was obtained by debromination of the 10α-CF3-10-bromodeoxoartemisinin in the presence of tributyltin hydride at reflux in toluene without alteration of the endoperoxide bridge. It presented a reasonable antimalarial activity.