408359-07-9

Basic information

• Product Name: 3-Bromo-2-formylpyrrole
• Synonyms: 3-Bromo-2-formylpyrrole;3-Bromo-1H-pyrrole-2-carbaldehyde;3-Bromo-1H-pyrrole-2-carboxaldehyde
• CAS NO: 408359-07-9
• Molecular Formula: C5H4BrNO
• Molecular Weight: 173.99536
• Mol File: 408359-07-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-Bromo-2-formylpyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-formylpyrrole(408359-07-9)
• EPA Substance Registry System: 3-Bromo-2-formylpyrrole(408359-07-9)

Safety Data

• Hazardous Substances Data: 408359-07-9(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-formylpyrrole is a chemical compound with the molecular formula C5H4BrNO. It is a pyrrole derivative with a bromine atom and a formyl group attached to the pyrrole ring. 3-Bromo-2-formylpyrrole is used as a building block in organic synthesis and serves as a key intermediate in the preparation of various pharmaceutical and agrochemical products. 3-Bromo-2-formylpyrrole is known for its diverse reactivity and can undergo various chemical reactions, such as nucleophilic substitution and condensation, to yield a wide range of functionalized pyrrole derivatives. Its unique structure and reactivity make it a valuable tool in the field of medicinal and agricultural chemistry.

Upstream product

• 233770-16-6 (E)-N-(4,4'-diethoxy-1-styrylbut-2-ynyl)-4-toluenesulfonamide 
• 168030-84-0 (E)-3-bromo-1-tosyl-2-styrylpyrrole 
• 408359-06-8 3-bromo-N-tosylpyrrole-2-carboxaldehyde 

Downstream Products

• 1191423-03-6 3-(phenylethynyl)-1-(2-(trimethylsilyl)ethoxymethyl)-1H-pyrrol-2-carbaldehyde 

Relevant articles and documents

Studies of palladium-catalyzed coupling reactions for preparation of hindered 3-arylpyrroles relevant to (-)-rhazinilam and its analogues

Suzuki cross-coupling reactions of 3-pyrroleboronic acid derivatives with haloaromatics and the reverse process i.e., the coupling of 3-iodo(bromo)pyrroles with arylboronic acids have been investigated as a potential key step in the synthesis of (-)-rhazinilam and analogues. It was found that 3-iodo-2-formyl-1-tosylpyrroles efficiently coupled with a variety of arylboronic acids in the presence of PdCl2(dppf) as catalyst. This catalytic system is compatible with a broad spectrum of arylboronic acids - electron-rich, electron-poor, hindered, heterocyclic - which easily coupled with the pyrrole substrate.