408359-47-7Relevant academic research and scientific papers
Synthesis of N,N-dimethyl-2-amino-1,2-dicyclohexylethanol and its application in the enantioselective conjugate addition of diethylzinc to enones: A convenient upgrade of the chiral ligand via hydrogenation
Tong, Pui-Erh,Li, Pei,Chan, Albert S.C.
, p. 2301 - 2304 (2001)
The effectiveness of N,N-dimethyl-2-amino-1,2-diphenylethanol as a chiral ligand was significantly improved via simple hydrogenation of the phenyl rings. Both the catalytic activity and the enantioselectivity of the resulting new ligand in the asymmetric
A highly efficient organocatalyst for direct Aldol reactions of ketones with aldedydes
Tang, Zhuo,Yang, Zhi-Hua,Chen, Xiao-Hua,Cun, Lin-Feng,Mi, Ai-Qiao,Jiang, Yao-Zhong,Gong, Liu-Zhu
, p. 9285 - 9289 (2007/10/03)
L-Proline amides derived from various chiral β-amino alcohols that bear substituents with various electron natures at their stereogenic centers are prepared and evaluated for catalyzing the direct Aldol reaction of 4-nitrobenzaldehyde with acetone. Cataly
An amino alcohol ligand for highly enantioselective addition of organozinc reagents to aldehydes: Serendipity rules
Nugent, William A.
, p. 2133 - 2136 (2007/10/03)
(matrix presented) Amino alcohol 4 (or its enantiomer) is prepared in two simple steps. Commercial (1R,2S)-2-amino-1,2-diphenylethanol is dialkylated with bis(2-bromoethyl) ether. Subsequent hydrogenation over 5% Rh on alumina in the presence of morpholine unexpectedly stops at the hexahydro derivative 4. Amino alcohol 4 promotes the enantioselective addition of diethylzinc to aldehydes at room temperature in up to 99% enantiomeric excess.
