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408360-05-4

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408360-05-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 408360-05-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,8,3,6 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 408360-05:
(8*4)+(7*0)+(6*8)+(5*3)+(4*6)+(3*0)+(2*0)+(1*5)=124
124 % 10 = 4
So 408360-05-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO4S2/c1-8-2-4-9(5-3-8)18(15,16)12-6-7-17-10(12)11(13)14/h2-5,10H,6-7H2,1H3,(H,13,14)/p-1/t10-/m1/s1

408360-05-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(4-methylphenyl)sulfonyl-1,3-thiazolidine-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:408360-05-4 SDS

408360-05-4Upstream product

408360-05-4Downstream Products

408360-05-4Relevant articles and documents

Synthesis and 11β hydroxysteroid dehydrogenase 1 inhibition of thiazolidine derivatives with an adamantyl group

Kwon, Sung Wook,Kang, Seung Kyu,Lee, Jae Hong,Bok, Joo Hwan,Kim, Chi Hyun,Rhee, Sang Dal,Jung, Won Hoon,Kim, Hee Youn,Bae, Myung Ae,Song, Jin Sook,Ha, Duck Chan,Cheon, Hyae Gyoung,Kim, Ki Young,Ahn, Jin Hee

scheme or table, p. 435 - 439 (2011/02/28)

A new series of thiazolidine derivatives with an adamantyl group was synthesized and evaluated for their ability to inhibit 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). Our initial compound 5a showed a weak inhibitory activity. Significant improvements in potency were achieved by substituent modification. The potent compound 8g (E) showed good in vitro inhibitory activity toward human 11β-HSD1, selectivity toward 11β-HSD2, metabolic stability, pharmacokinetic, and safety profile. Furthermore, this compound significantly inhibited 11β-HSD1 activity in rat and monkey models, and showed improved glycemic control in KKAy mice.

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