408366-46-1

Basic information

• Product Name: N-(4-Hydroxy-3-nitrophenyl)-4'-(trifluoromethyl)-1,1'-biphenyl-2-carboxamide
• CAS NO: 408366-46-1
• Molecular Weight: 402.329
• Mol File: 408366-46-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-Hydroxy-3-nitrophenyl)-4'-(trifluoromethyl)-1,1'-biphenyl-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Hydroxy-3-nitrophenyl)-4'-(trifluoromethyl)-1,1'-biphenyl-2-carboxamide(408366-46-1)
• EPA Substance Registry System: N-(4-Hydroxy-3-nitrophenyl)-4'-(trifluoromethyl)-1,1'-biphenyl-2-carboxamide(408366-46-1)

Safety Data

• Hazardous Substances Data: 408366-46-1(Hazardous Substances Data)

Upstream product

• 119-34-6 4-amino-2-nitrophenol 
• 180340-74-3 4'-trifluoromethylbiphenyl-2-carbonyl chloride 

Downstream Products

• 408366-47-2 N-{3-Nitro-4-[2-(2-pyridinyl)ethoxy]phenyl}-4'-(trifluoromethyl)-1,1'-biphenyl-2-carboxamide 

Relevant articles and documents

Benzamide compounds as apo b secretion inhibitors

The present invention relates to compounds of the formula (I) wherein R1 and R2 are each independently lower alkyl lower alkenyl, acyl, amino, lower alkoxy, lower cycloalkyloxy, aryl, aryloxy, sulfooxy, mercapto, sulfo, hydrogen, halogen, nitro, cyano or hydroxy, or may form a ring structure; Q1 is N or CH; L is optionally substituted unsaturated 3 to 10-membered heterocyclic group; X is optionally substituted monocyclic arylene or monocyclic heteroarylene; Y is -(A1)m-(A2)n-(A4)k-; Z is directbond, —CH2-, —NH— or —O—; and R is hydrogen or lower alkyl, or a salt thereof The compounds of the present invention inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.