408367-99-7

Basic information

• Product Name: 3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBOXYLIC ACID
• Synonyms: RARECHEM AL BE 1365;AKOS BAR-0248;3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBOXYLIC ACID;2-(3-TrifluoroMethylphenyl)benzoic acid;3'-Trifluoromethylbiphenyl-2-carboxylic acid
• CAS NO: 408367-99-7
• Molecular Formula: C14H9F3O2
• Molecular Weight: 266.22
• Mol File: 408367-99-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 350.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.326±0.06 g/cm3(Predicted)
• PKA: 3.79±0.36(Predicted)
• CAS DataBase Reference: 3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBOXYLIC ACID(408367-99-7)
• EPA Substance Registry System: 3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBOXYLIC ACID(408367-99-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 408367-99-7(Hazardous Substances Data)

Usage

General Description

3'-(Trifluoromethyl)[1,1'-biphenyl]-2-carboxylic acid is a synthetic chemical compound featuring both aromatic and carboxylic acid properties. The formation of the compound involves Coupling of two ring structures, namely, a biphenyl ring and a trifluoromethyl group. The resulting acid exhibits various chemical activities, such as providing electron-withdrawing and dipole-creating properties due to the trifluoromethyl group attached to one of its phenyl rings. Furthermore, the presence of a carboxylic acid functional group opens avenues for further reaction possibilities, including esterification and amide formation. However, information related to its specific applications, risks, or toxicity are not readily available, suggesting it might be majorly used in research and experimental settings.

Upstream product

• 773134-23-9 C₁₅H₁₁F₃O₂ 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 

Relevant articles and documents

Palladium-catalyzed intramolecular aromatic C-H acylation of 2-arylbenzoyl fluorides

The catalytic intramolecular cyclization of acyl fluorides using a Pd(OAc)2/PCy3 system is described. A wide range of 2-arylbenzoyl fluoride derivatives can be used as fluorenone precursors and the reaction proceeds via an intramolecular coupling between aromatic C-H bonds with acyl C-F bonds. The reaction can be applied to the synthesis of indenofluorenedione derivatives and to the construction of other molecules with fivemembered rings.

General and practical carboxyl-group-directed remote C-H oxygenation reactions of arenes

Two methods for remote aromatic C-H oxygenation reactions, have been developed. Method1, the Cu-catalyzed oxygenation reaction, is highly efficient for cyclization of electron-neutral and electron-rich biaryl carboxylic acids into 3,4-benzocoumarins. Method2, the K2S2O 8-mediated oxygenation reaction, is more general and practical for cyclization of substrates with electron-donating and -withdrawing groups (see scheme). Copyright