408367-99-7

Usage

Uses

Used in Research and Experimental Settings:
3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBOXYLIC ACID is used as a chemical intermediate for [application reason] in the field of organic chemistry. Its unique structure and properties make it a valuable compound for exploring new chemical reactions and syntheses.
Used in Pharmaceutical Industry:
3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBOXYLIC ACID is used as a building block for the development of new pharmaceutical compounds due to its potential to modulate various biological activities. The presence of the trifluoromethyl group and carboxylic acid functionality can contribute to the compound's interaction with biological targets and improve its pharmacological properties.
Used in Material Science:
3'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-2-CARBOXYLIC ACID is used as a component in the synthesis of advanced materials, such as polymers and coatings, due to its aromatic and carboxylic acid properties. The trifluoromethyl group can enhance the stability and performance of these materials, while the carboxylic acid group can facilitate cross-linking and other reactions to improve their properties.

Upstream product

• 773134-23-9 C₁₅H₁₁F₃O₂ 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 

Relevant academic research and scientific papers

Palladium-catalyzed intramolecular aromatic C-H acylation of 2-arylbenzoyl fluorides

The catalytic intramolecular cyclization of acyl fluorides using a Pd(OAc)2/PCy3 system is described. A wide range of 2-arylbenzoyl fluoride derivatives can be used as fluorenone precursors and the reaction proceeds via an intramolecular coupling between aromatic C-H bonds with acyl C-F bonds. The reaction can be applied to the synthesis of indenofluorenedione derivatives and to the construction of other molecules with fivemembered rings.

Pd-catalyzed C-H lactonization for expedient synthesis of biaryl lactones and total synthesis of cannabinol

A practical Pd(II)/Pd(IV)-catalyzed carboxyl-directed C-H activation/C-O cyclization to construct biaryl lactones has been developed. The synthetic utility of this new reaction was demonstrated in an atom-economical and operationally convenient total synthesis of the natural product cannabinol from commercially available starting materials, with the newly developed method used for two key steps.

General and practical carboxyl-group-directed remote C-H oxygenation reactions of arenes

Two methods for remote aromatic C-H oxygenation reactions, have been developed. Method1, the Cu-catalyzed oxygenation reaction, is highly efficient for cyclization of electron-neutral and electron-rich biaryl carboxylic acids into 3,4-benzocoumarins. Method2, the K2S2O 8-mediated oxygenation reaction, is more general and practical for cyclization of substrates with electron-donating and -withdrawing groups (see scheme). Copyright

N-BENZODIOXOLYL, N-BENZODIOXANYL AND N-BENZODIOXEPINYL ARYLCARBONXAMIDE DERIVATIVES, AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

The present invention relates to a compound of the formula (I) : in which T, A, R, B Xi, Yi and n are as defined in Claim 1, and to the pharmaceutically usable derivatives, solvates and stereoisomers thereof, comprising a mixture thereof in all proportions, which can be used in the treatment of dyslipidaemia, and to pharmaceutical compositions comprising them.