40838-32-2

Usage

InChI:InChI=1/C6H5BrO4/c7-6-5(10)4(9)1-3(2-8)11-6/h1,8,10H,2H2

Upstream product

• 501-30-4 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 

Downstream Products

• 1143293-88-2 C₁₃H₁₁BrO₄ 
• 1449748-85-9 N-[2-(tert-butyldiphenylsiloxy)ethyl]-6-[2-(6-chloroquinolin-2-yl)thiazol-4-yl]-5-methoxy-4-oxo-4H-pyran-2-carboxamide 
• 1449748-86-0 N-[2-(tert-butyldiphenylsilyloxy)ethyl]-6-[2-(6-chloroquinolin-2-yl)thiazol-4-yl]-5-methoxy-1-methyl-4-oxo-1,4-dihydropyridine-2-carboxamide 
• 1449748-88-2 3-bromo-N-(2-(tert-butyldiphenylsiloxy)ethyl)-6-(2-(6-chloroquinolin-2-yl)thiazol-4-yl)-5-methoxy-1-methyl-4-oxo-1,4-dihydropyridine-2-carboxamide 
• 1394231-88-9 N-(2-(tert-butyldiphenylsiloxy)ethyl)-6-(2-(6-chloroquinolin-2-yl)thiazol-4-yl)-5-methoxy-1-methyl-3-(methylthio)-4-oxo-1,4-dihydropyridine-2-carboxamide 

Relevant academic research and scientific papers

Synthesis of lodopyridone

The total synthesis of the unusual 4-pyridone marine metabolite lodopyridone has been achieved by late stage manipulation of the related 4-pyrone. Key reactions include a Suzuki-Miyaura coupling to form the tetracyclic core and a modified Corey-Ganem-Gilman reaction to install the ethanolamide side-chain.

SMALL MOLECULE INSULIN MIMETICS ABSENT QUINONES

Compounds of Formula I are described along with pharmaceutical formulations thereof, and methods of treating disorders such as diabetes and neurodegenerative diseases with such compounds.