408502-23-8

Basic information

• Product Name: 2-METHOXYLYPYRIDINE-4-BORONIC ACID PINACOLATE
• Synonyms: 2-METHOXYLYPYRIDINE-4-BORONIC ACID PINACOLATE;2-methoxypyridine-4-boronic acid pinacolate;2-METHOXYPYRIDINE-4-BORONIC ACID PINACOL ESTER;2-Methoxylypyrinine-4-boronic acid pinacolate;2-Methoxy-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
• CAS NO: 408502-23-8
• Molecular Formula: C₁₂H₁₈BNO₃
• Molecular Weight: 235.09
• Product Categories: Pyridine
• Mol File: 408502-23-8.mol
• Article Data: 15

Chemical Properties

• Melting Point: 36 °C
• Boiling Point: 373.317oC at 760 mmHg
• Flash Point: 179.576oC
• Appearance: /
• Density: 1.111g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility: soluble in Methanol
• PKA: 2.56±0.10(Predicted)
• CAS DataBase Reference: 2-METHOXYLYPYRIDINE-4-BORONIC ACID PINACOLATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXYLYPYRIDINE-4-BORONIC ACID PINACOLATE(408502-23-8)
• EPA Substance Registry System: 2-METHOXYLYPYRIDINE-4-BORONIC ACID PINACOLATE(408502-23-8)

Safety Data

• Hazardous Substances Data: 408502-23-8(Hazardous Substances Data)

Usage

General Description

2-Methoxylypyridine-4-Boronic Acid Pinacolate is a chemical compound often used in organic synthesis and pharmaceutical research. Belonging to a class of boronic acids, it serves as a crucial component in creating biologically active molecules and specific drugs due to its ability to facilitate the Suzuki-Miyaura cross-coupling reaction. This reaction is pivotal in establishing carbon-carbon bonds, essential to creating diverse molecular frameworks useful in drug discovery. As an advanced intermediate, 2-Methoxylypyridine-4-Boronic Acid Pinacolate plays a significant role in synthetic and medicinal chemistry.

InChI:InChI=1/C12H20BNO4/c1-11(2,15)12(3,4)18-13(16)9-6-7-14-10(8-9)17-5/h6-8,15-16H,1-5H3

Upstream product

• 1628-89-3 2-methoxypyridine 
• 73183-34-3 bis(pinacol)diborane 
• 98197-72-9 (2-iodo-pyridin-4-yl)-dimethyl-amine 
• 72141-44-7 4-chloro-2-methoxypyridine 
• 14395-39-2 2-methoxy-4-nitropyridine N-oxide 
• 20773-98-2 2-methoxypyridine N-oxide 
• 20265-39-8 4-amino-2-methoxypyridine 
• 100367-39-3 4-bromo-2-methoxypyridine 
• 14432-12-3 4-Amino-2-chloropyridine 

Downstream Products

• 100848-70-2 2-methoxy-4-methyl-pyridine 
• 53698-46-7 2-methoxy-4-phenyl-pyridine 
• 1245646-00-7 2'-methoxy-N-methyl-4,4'-bipyridin-2-amine 
• 1262298-58-7 3-(1-(4-(2-methoxypyridin-4-yl)phenyl)cyclopropyl)-6-(2-methylallyl)-6-phenyl-1,3-oxazinan-2-one 
• 1260494-22-1 tert-butyl 8-(2-oxo-4-(6-(trifluoromethyl)pyridazin-3-yl)pyridin-1(2H)-yl)-6-tosyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate 
• 1260493-86-4 tert-butyl 8-(2-oxo-4-(6-(trifluoromethyl)pyridazin-3-yl)pyridin-1(2H)-yl)-6-tosyl-1,2,4,5-tetrahydroazepino[4,5-b]indole-3(6H)-carboxylate 

Relevant articles and documents

para-Selective C?H Borylation of (Hetero)Arenes by Cooperative Iridium/Aluminum Catalysis

para-Selective C?H borylation of benzamides and pyridines has been achieved by cooperative iridium/aluminum catalysis. A combination of iridium catalysts commonly employed for arene C?H borylation and bulky aluminum-based Lewis acid catalysts provides an unprecedented strategy for controlling the regioselectivity of C?H borylation to give variously substituted (hetero)arylboronates, which are versatile synthetic intermediates for complex multi-substituted aromatic compounds.

METHODS FOR PRODUCING BORYLATED ARENES

Methods for the selective borylation of arenes, including arenes substituted with an electron-withdrawing group (e.g., 1-chloro-3-fluoro-2-substituted benzenes) are provided. The methods can be used, in some embodiments, to efficiently and regioselectivel

Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2′-fluoro-3′-(substituted pyridinyl)-7- deschloroepibatidine analogues

2′-Fluoro-3-(substituted pyridine)epibatidine analogues 7a-e and 8a-e were synthesized, and their in vitro and in vivo nAChR properties were determined. 2′-Fluoro-3′-(4″-pyridinyl)deschloroepibatidine (7a) and 2′-fluoro-3′-(3″-pyridinyl)deschloroepibatidi