40851-98-7

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
5-CHLORO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE is used as a research compound for its potential pharmacological properties, particularly its ability to act as an antagonist of certain receptors in the human body. This makes it a valuable tool in the discovery and development of new drugs targeting specific biological pathways.
Used in the Treatment of Medical Conditions:
5-CHLORO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE is under investigation for its potential applications in the treatment of various medical conditions. Its specific mechanism of action and therapeutic effects are being studied to determine its suitability as a treatment option for certain diseases or disorders.
Used in Scientific Study and Analysis:
As an important target for further research, 5-CHLORO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE is utilized in scientific studies to analyze its chemical properties, biological activities, and potential interactions with human physiology. This research aims to enhance understanding of the compound and its possible applications in medicine.

InChI:InChI=1/C6H4ClN3O/c7-4-2-1-3-5(9-4)10-6(11)8-3/h1-2H,(H2,8,9,10,11)

Upstream product

• 40851-95-4 6-chloropyridine-2,3-diamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 89660-20-8 5-chloro-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one 
• 89660-21-9 1,3-dimethyl-5-chloroimidazo<4,5-b>pyridin-2-one 

Relevant academic research and scientific papers

Synthesis and biological activity of splitomicin analogs targeted at human NAD+-dependent histone deacetylases (sirtuins)

Small molecules interfering with posttranslational modification of histones are of interest as tools to study epigenetic regulation of gene transcription. Specifically, drugs that interfere with histone deacetylation could be useful to induce differentiation, growth arrest as well as apoptotic cell death in tumor cells. One class of histone deacetylases is known as sirtuins some of which (Saccharomyces cerevisiae Sir2) are for example inhibited by the lactone splitomicin leading to telomeric silencing in yeast. However, splitomicin is only a micromolar inhibitor of yeast Sir2 and does not inhibit human subtypes and the lactone is prone to hydrolytic ring opening. In preliminary SAR-studies, splitomicin analogs lacking this hydrolytically labile ring were described as inactive while the naphthalene moiety could successfully be replaced by smaller aromatic rings in a fragment-like dihydrocoumarin. Here we report the synthesis and biological activity of a series of hydrolytically stable analogs with activity against human SIRT1 and 2. These comparatively small compounds characterized by high ligand efficiency are used as a starting point toward the development of specific inhibitors of histone deacetylases from the class of sirtuins.

Compounds with antiulcer and antisecretory activity. III. N-substituted imidazolones condensed with nitrogen-containing heteroaromatic rings

The syntheses of imidazo[4,5-b]pyridin-2-ones and -thiones, imidazo [4,5-c]pyridin-2-ones and 7,9-dihydro-8H-purin-8-ones arylated (or heteroarylated) at an imidazolone nitrogen are reported. Only some compounds of the first series have marked antisecreto