408525-71-3Relevant academic research and scientific papers
Reduction of 1,3-Diimines. A New and General Method of Synthesis of γ-Diamines, β-Amino Ketones, and Derivatives with Two and Three Chiral Centers
Barluenga, Jose,Olano, Bernardo,Fustero, Santos
, p. 2255 - 2259 (2007/10/02)
1,3-Diimes 1 are easily reduced with Na/i-PrOH to afford unsymmetrical N-substituted γ-diamines 8 in nearly quantitative yields.Since three chiral centers are generated, compounds 8 are isolated as a mixture of diastereoisomers which are easily separated.
