40881-98-9Relevant academic research and scientific papers
Naphthoquinone phosphorus amide compounds and their use as cell death inducer in the use of iron (by machine translation)
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Paragraph 0033-0034, (2017/09/12)
The present invention discloses a series of naphthoquinone phosphorus amide compounds and their use as cell death inducer in the use of the iron. The naphthoquinone phosphorus amide compounds have the general formula I structure shown. Research shows that, the compound capable of inducing cell death in iron, thereby inhibiting cell, in particular the purpose of tumor cell proliferation. The invention provides a novel cell-death inducing agent, for the treatment of tumor diseases also provides a kind of new technical means. (by machine translation)
Synthesis of N, N-dialkyl phosphoramidic dichloride from dialkyl amine and phosphoryl chloride using basic anion exchange polymer resins/beads
Kushwaha, Brijesh K.,Gupta, Hemendra K.,Shinde
body text, p. 361 - 364 (2010/08/20)
An efficient and operationally simple method is developed for the syndesis of N, N-dialkyl phosphoramidic dichloride from dialkyl amine and phosphoryl chloride using basic anion exchange polymer resins/beads. In me reaction, polymer resin acts as a scavenger for HCl produced as by-product and desired product is distilled under vacuum. Reaction afforded N, N-dialkyl phosphoramidic dichloride in 3-4 hours with excellent yields from corresponding dialkylamine and phosphoryl chloride.
