40891-03-0Relevant articles and documents
Solvent-free synthesis of monoacylaminals from the reaction of amides and aminals as precursors in carbinolamide synthesis
Sansone, Matthew F.,Koyanagi, Takaoki,Przybyla, David E.,Nagorski, Richard W.
supporting information; experimental part, p. 6031 - 6033 (2010/11/21)
A solvent-free method of generating monoacylaminals by heating the amide and aminal starting materials in the presence of one another has been developed. Yields were generally between 45% and 65% with the monoacylaminal being isolated, needing no further purification after drying under high vacuum.
A new protocol for the preparation of aminals from aromatic aldehydes and their facile conversion to phosphonates
Dezfuli, Mohammad Karimi,Saidi, Mohammad Reza
, p. 89 - 96 (2007/10/03)
A new and fast method for the preparation of aminals is reported from the reaction of aromatic aldehydes and secondary amines in the presence of potassium carbonate in high yields. The aminal can be converted to the corresponding iminum salt in reaction with acetyl chloride very easily and in very short time with high yield. Addition of trialkylphosphite, as one possible nucleophile, to the prepared iminium salt produces the α-amino phosphonate in very high yield.
Novel synthesis of α-acetylstyrylphosphonates
Sakoda,Matsumoto,Seto
, p. 705 - 713 (2007/10/02)
α-Acetylstyrylphosphonates were conveniently synthesized from 2-oxopropylphosphonates and substituted (dimorpholinomethyl)-benzenes (animals). 4-Benzylidenemorpholinium carboxylates, generated from animals by the action of α-halo acids, reacted with the phosphonates to give the products by elimination of the amine. The yields were influenced by the nature of substituents and their position in the phenyl ring and could be improved by adjustment of the acidities of the reacted acids. α-Acetylstyrylphosphonates containing various substituents on every position (at the 2-, 3-, or 4-position) in the phenyl ring were obtained generally in excellent yields using monochloroacetic acid.
