40893-69-4

Basic information

• Product Name: 1-CHLORO-3-MORPHOLIN-4-YLPROPAN-2-OL
• Synonyms: 1-CHLORO-3-MORPHOLIN-4-YLPROPAN-2-OL;1-chloro-3-Morpholinopropan-2-ol;alpha-(Chloromethyl)-4-morpholineethanol
• CAS NO: 40893-69-4
• Molecular Formula: C₇H₁₄ClNO₂
• Molecular Weight: 179.64
• Mol File: 40893-69-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 293.326°C at 760 mmHg
• Flash Point: 131.199°C
• Appearance: /
• Density: 1.183g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.49
• CAS DataBase Reference: 1-CHLORO-3-MORPHOLIN-4-YLPROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-3-MORPHOLIN-4-YLPROPAN-2-OL(40893-69-4)
• EPA Substance Registry System: 1-CHLORO-3-MORPHOLIN-4-YLPROPAN-2-OL(40893-69-4)

Safety Data

• Hazardous Substances Data: 40893-69-4(Hazardous Substances Data)

Usage

Synonyms

N-chloromorpholin-4-ylpropan-2-ol

Chemical class

Chloroalcohols

Physical state

White solid

Molecular weight

179.63 g/mol

Uses

a. Reagent in organic synthesis
b. Intermediate in pharmaceutical and agrochemical production

Properties

a. Strong antimicrobial activity
b. Strong antifungal properties

Applications

a. Preservative in various products
b. Potential treatment for various diseases (under study)

Field of relevance

Medicinal chemistry

InChI:InChI=1/C7H14ClNO2/c8-5-7(10)6-9-1-3-11-4-2-9/h7,10H,1-6H2

Upstream product

• 110-91-8 morpholine 
• 106-89-8 epichlorohydrin 

Downstream Products

• 6270-19-5 4-(oxiran-2-ylmethyl)morpholine 
• 55212-21-0 1-morpholino-3-phenylaminopropan-2-ol 
• 947394-05-0 3-(N-ethyl-N-phenylamino)-1-morpholinopropan-2-ol 

Relevant articles and documents

Syntheses on the basis of 4-(oxiran-2-ylmethyl)morpholine

4-(Oxiran-2-ylmethyl)morpholine was synthesized and converted into new morpholino derivatives of propan-2-ols and butan-4-olides.

A facile and general synthesis of 2β-aminosteroids

A facile and general synthesis of 2β-aminosteroids in high yields from 2,3α-epoxy-5α-androstan-17-one by regioselective aminolysis is developed using a zinc chloride/water catalytic system. The reaction is successful with both aliphatic and aromatic amine

Treatment of excessive osteolysis with indolinone compounds

Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.