40893-69-4

Usage

Synonyms

N-chloromorpholin-4-ylpropan-2-ol

Chemical class

Chloroalcohols

Physical state

White solid

Molecular weight

179.63 g/mol

Uses

a. Reagent in organic synthesis
b. Intermediate in pharmaceutical and agrochemical production

Properties

a. Strong antimicrobial activity
b. Strong antifungal properties

Applications

a. Preservative in various products
b. Potential treatment for various diseases (under study)

Field of relevance

Medicinal chemistry

InChI:InChI=1/C7H14ClNO2/c8-5-7(10)6-9-1-3-11-4-2-9/h7,10H,1-6H2

Upstream product

• 110-91-8 morpholine 
• 106-89-8 epichlorohydrin 

Downstream Products

• 55212-21-0 1-morpholino-3-phenylaminopropan-2-ol 
• 6270-19-5 4-(oxiran-2-ylmethyl)morpholine 
• 947394-05-0 3-(N-ethyl-N-phenylamino)-1-morpholinopropan-2-ol 

Relevant academic research and scientific papers

Syntheses on the basis of 4-(oxiran-2-ylmethyl)morpholine

4-(Oxiran-2-ylmethyl)morpholine was synthesized and converted into new morpholino derivatives of propan-2-ols and butan-4-olides.

Synthesis and application of Cu(II) immobilized MCM-41 based solid Lewis acid catalyst for aminolysis reaction under solvent-free condition

In this paper, a Cu(II) immobilized periodic mesoporous organosilica (PMOs) was synthesized and used as a reusable solid Lewis acid catalyst for the aminolysis of epoxides under solvent-free conditions. An amide-based ligand, L-propylsilyl (1) having a specific binding pocket was prepared and fabricated on mesoporous MCM-41 to produce mesoporous organosilica L-propylsilyl@MCM-41 (2). Further, it has been utilized for anchoring Cu(II) ions under controlled reaction conditions to yield solid Lewis acid catalyst Cu(II)-L-propylsilyl@MCM-41 (3). The synthesized catalyst 3 exhibits significantly higher catalytic activity for aminolysis compared to hitherto known solid Lewis acid catalysts. An extensive range of β-amino alcohols with high regio and stereoselectivity were prepared by using catalyst 3. The catalyst was recovered easily and reused eight times without any loss in its catalytic activity. Furthermore, the synthesis of clinically significant propranolol (β-blocker) from α- naphthyl glycidyl ether was attained successfully using catalyst 3 in a very decent yield.

A facile and general synthesis of 2β-aminosteroids

A facile and general synthesis of 2β-aminosteroids in high yields from 2,3α-epoxy-5α-androstan-17-one by regioselective aminolysis is developed using a zinc chloride/water catalytic system. The reaction is successful with both aliphatic and aromatic amine

Microwave-assisted ring opening of epoxides: A general route to the synthesis of 1-aminopropan-2-ols with anti malaria parasite activities

A series of 1-aminopropan-2-ols were synthesized and evaluated against two strains of malaria, Plasmodium falciparum FCR3 (chloroquine-resistant) and 3D7 (chloroquine-sensitive). Microwave-assisted ring opening of epoxides (aryl and alkyl glycidyl ethers,

Treatment of excessive osteolysis with indolinone compounds

Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.

3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as portein kinase inhibitors

The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Treatment of acute myeloid leukemia with indolinone compounds

A method of treating acute myeloid leukemia in patient positive for FLT-3-ITD is described. The treatment is accomplished by administration of a compound of Formula I or II as defined herein.

Microwave-assisted aminolysis of epoxides under solvent-free conditions catalyzed by montmorillonite clay

The reaction of primary and secondary amines with epoxides in the presence of montmorillonite K10 clay, under solvent-free conditions and microwave irradiation affords high yields of β-amino alcohols.

Structure and Reactivity of Oxirane Chemical Modifiers for Gelatin

New chemical modifiers for gelatin, glycidylamines, are synthesized.Acid-base properties of glycidylamines and the kinetics of reactions of oxirane compounds with nucleophilic reagents, among them aqueous solution of gelatin, are studied.