40899-71-6Relevant articles and documents
Substituent Effects on the Acid Hydration of Acetylenes
Allen, Annette D.,Chiang, Yvonne,Kresge, A. Jerry,Tidwell, Thomas T.
, p. 775 - 779 (1982)
The rates of hydration in aqueous sulfuric acid of 1-butyne, 2-butyne, 1-hexyne, 1-cyclopropylacetylene, and 1-butene are reported, together with rates in D2SO4 for the alkynes plus 3-hexyne.All of the compounds are proposed to react through the AdE2 mechanism of rate-limiting protonation on carbon.A general correlation of logkH+(alkyne)/log kH+(alkene) is observed, whose slope of 1.25 is a quantitative measure of the greater sensitivity to substituent effects of alkynes compared to alkenes in protonation.
Rationally designed N-phenylsulfonylindoles as a tool for the analysis of the non-basic 5-HT6R ligands binding mode
Staroń, Jakub,Bugno, Ryszard,Pietru?, Wojciech,Sata?a, Grzegorz,Mordalski, Stefan,Warszycki, Dawid,Hogendorf, Agata,Hogendorf, Adam S.,Kalinowska-T?u?cik, Justyna,Lenda, Tomasz,Pilarski, Bogus?aw,Bojarski, Andrzej J.
supporting information, (2020/10/26)
Among all of the monoaminergic receptors, the 5-HT6R has the highest number of non-basic ligands (approximately 5% of compounds stored in 25th version of ChEMBL database have the strongest basic pKa below 5, calculated using the Instant JChem c
The generation of Indole-2,3-quinodimethanes from the Deamination of 1,2,3,4-Tetrahydropyrrolo[3,4-b]indoles
Rinderspacher, Alison,Gribble, Gordon W.
, (2020/01/31)
A novel generation of indole-2,3-quinodimethanes via the deamination of 1,2,3,4-tetrahydropyrrolo[s3,4-b]indoles is reported.
