4090-29-3 Usage
Uses
Used in Enzyme Inhibition Assays:
Thionicotinamide adenine dinucleotide is used as a substrate analog for the inhibition assay of S-adenosyl-l-homocysteine (AdoHcy) hydrolases (SAHH). The application reason is that Thio-NAD provides a more sensitive detection method for enzyme activity due to its increased absorbance at 405 nm.
Used in Analytical Chemistry:
Thionicotinamide adenine dinucleotide (thio-NAD) is used as a NAD derivative in the determination of Carnitine by an enzymic cycling method with carnitine dehydrogenase. The application reason is that Thio-NAD offers improved sensitivity and accuracy in measuring carnitine levels, which is essential for various diagnostic and research purposes.
Used in Pharmaceutical Research:
Thionicotinamide adenine dinucleotide (thio-NAD) is used in the development and optimization of novel drug delivery systems, particularly for enhancing the efficacy of gallotannin against cancer cells. The application reason is that Thio-NAD can be employed as a carrier for gallotannin delivery, aiming to improve its bioavailability and therapeutic outcomes in cancer treatment.
Biological Activity
Thionicotinamide adenine dinucleotide (sNAD) is an analog of coenzyme nicotinamide adenine dinucleotide (NAD) and NADH. sNAD is a potential inhibitor of NAD+ kinase. NAD+ kinase modulates NAD levels, contributing to cytotoxicity in cancer cells.
Biochem/physiol Actions
Thionicotinamide adenine dinucleotide (sNAD) is an analog of coenzyme nicotinamide adenine dinucleotide (NAD) and NADH. sNAD is a potential inhibitor of NAD+ kinase. NAD+ kinase modulates NAD levels, contributing to cytotoxicity in cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 4090-29-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,9 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 4090-29:
(6*4)+(5*0)+(4*9)+(3*0)+(2*2)+(1*9)=73
73 % 10 = 3
So 4090-29-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H27N7O13P2S/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(40-21)6-38-43(35,36)41-42(33,34)37-5-10-13(29)15(31)20(39-10)27-3-1-2-9(4-27)18(23)44/h1-4,7-8,10-11,13-16,20-21,29-30,32H,5-6H2,(H2,23,44)(H,33,34)(H,35,36)(H2,22,24,25)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
