409060-22-6Relevant academic research and scientific papers
Synthesis and Regioselective N-2 Functionalization of 4-Fluoro-5-aryl-1,2,3-NH-triazoles
Motornov, Vladimir A.,Tabolin, Andrey A.,Novikov, Roman A.,Nelyubina, Yulia V.,Ioffe, Sema L.,Smolyar, Ivan V.,Nenajdenko, Valentine G.
, p. 6851 - 6860 (2017)
A new efficient synthetic route to 4-fluoro-5-aryl-1,2,3-NH-triazoles was elaborated. The reactions of NaN3 with aryl-substituted α-fluoronitroalkenes resulted in the domino construction of the target fluorinated triazoles. Sulfamic acid is an effective promoter for this heterocyclization. The subsequent functionalization reactions of the obtained triazoles proceed highly regioselectively at the N-2 position. The observed regioselectivity was supported by DFT calculations.
