409109-20-2

Upstream product

• 614-16-4 Benzoylacetonitrile 
• 24472-77-3 trimethyl-(2-oxo-2-phenylethyl)-ammonium bromide 
• 99-98-9 4-amino-N,N-dimethylaniline 
• 611-73-4 Benzoylformic acid 
• 25726-04-9 phenylglyoxylyl chloride 
• 70-11-1 α-bromoacetophenone 
• 16883-69-5 N-phenacylpyridinium bromide 
• 24423-91-4 4-dimethylamino-N-phenacylideneaniline N-oxide 
• 4714-86-7 2-(4-dimethylamino-phenylimino)-3-oxo-3-phenyl-propionitrile 

Relevant academic research and scientific papers

Novel synthesis of tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones via decarboxylative cyclization reaction of α-amino acids and α-ketoamides

An efficient and practical method was developed for the synthesis of tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones based on the decarboxylative cyclization reaction of α-ketoamides and proline. In most cases, tetrahydro-1H-pyrrolo[1,2-a]imidazol-2-ones were obtained with perfect diastereoselectivity to give trans-isomer in excellent yield.

Catalyst- and Additive-Free Chemoselective Transfer Hydrogenation of α-Keto Amides to α-Hydroxy Amides by Sodium Formate

A catalyst- and additive-free chemoselective transfer hydrogenation of α-keto amides to α-hydroxy amides is easily achieved by using sodium formate as a hydrogen source. The utility of this method is demonstrated by gram-scale synthesis and transformation of the resultant α-hydroxy amides into polysubstituted acetamides and 2-arylindole derivatives. Control experiments suggest that the NH group of α-keto amides is crucial for the chemoselective reduction through the formation of hydrogen bonds.