409113-10-6Relevant academic research and scientific papers
The scope of the direct proline-catalyzed asymmetric addition of ketones to imines
Notz, Wolfgang,Watanabe, Shin-Ichi,Chowdari, Naidu S.,Zhong, Guofu,Betancort, Juan M.,Tanaka, Fujie,Barbas III, Carlos F.
, p. 1131 - 1140 (2007/10/03)
A full account of catalytic direct asymmetric Mannich-type reactions is presented describing the scope of amino acid-catalyzed additions of unmodified ketones to a large variety of imines. These reactions are performed under very mild, operationally simpl
A highly enantioselective amino acid-catalyzed route to functionalized α-amino acids
Cordova, Armando,Notz, Wolfgang,Zhong, Guofu,Betancort, Juan M.,Barbas III, Carlos F.
, p. 1842 - 1843 (2007/10/03)
The development of syntheses providing enantiomerically pure α-amino acids has intrigued generations of chemists and been the subject of intense research. This report describes a general approach to functionalized α-amino acids based on catalytic asymmetr
