40914-43-0Relevant academic research and scientific papers
Short and efficient synthesis of 3-substituted 4-oxazolin-2-thiones and their reactivity
González-Romero, Carlos,Martínez-Palou, Rafael,Jiménez-Vázquez, Hugo A.,Fuentes, Aydeé,Jiménez, Fabiola,Tamariz, Joaquín
, p. 305 - 322 (2008/02/09)
A new synthesis of the substituted 4-oxazolin-2-thiones (1) and (14) is described by a regioselective tandem condensation reaction between α-ketols (4a-4b) and isothiocyanates (8). The use of dioxane as the solvent promotes the formation of the 4-methylen
REACTIONS OF 3-BUTINE-2-METHYL-2-OL WITH ISOTHIOCYANATES
Kutschy, Peter,Dzurilla, Milan,Kniezo, Ladislav,Bernat, Juraj,Imrich, Jan,et al.
, p. 1119 - 1126 (2007/10/02)
3-Butine-2-methyl-2-ol reacts with isothiocyanates in the presence of sodium hydride in dimethylformamide to give various products depending on structure of the isothiocyanate residue.Isothiocyanates with the NCS group bound to sp2 carbon atom (phenyl, 4-bromophenyl, and styryl isothiocyanates ) give the respective 1,3-oxazolidine derivatives.If the NCS group is bound to an sp3-hybridized carbon atom (ethyl and benzyl isothiocyanates), derivatives of 1,3-oxathiolane are formed.Acyl isothiocyanates (benzoyl and 3-phenylpropenoyl isothiocyanates) give products of substitution of the NCS group, viz. 1-butine-3-methyl-3-yl benzoate and 3-phenylpropenoic anhydride.
