40923-58-8

Basic information

• Product Name: -Valprolactone
• Synonyms: 4-Hydroxy-2-propylvaleric Acid Lactone;4-Hydroxyvalproic Acid -Lactone;Dihydro-5-methyl-3-propyl-2(3H)-furanone;-Hydroxy-α-ropylvleric Acid Lactone;-Valprolactone;-Hydroxy-a-ropylvleric Acid Lactone
• CAS NO: 40923-58-8
• Molecular Formula: C₈H₁₄O₂
• Molecular Weight: 142.1956
• Product Categories: Heterocyclic Compounds;Heterocycles;Metabolites & Impurities
• Mol File: 40923-58-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 106-110?C/4-5 torr
• Flash Point: 88.4 °C
• Appearance: /
• Density: 0.945 g/cm³
• Vapor Pressure: 0.0594mmHg at 25°C
• Refractive Index: 1.43
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: -Valprolactone(CAS DataBase Reference)
• NIST Chemistry Reference: -Valprolactone(40923-58-8)
• EPA Substance Registry System: -Valprolactone(40923-58-8)

Safety Data

• Hazardous Substances Data: 40923-58-8(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Liquid

Uses

Different sources of media describe the Uses of 40923-58-8 differently. You can refer to the following data:
1. A metabolite of valproic acid
2. A metabolite of valproic acid.

InChI:InChI=1/C8H14O2/c1-3-4-7-5-6(2)10-8(7)9/h6-7H,3-5H2,1-2H3

Upstream product

• 106421-06-1 (+/-)-5-methyl-3-prop-2-ynyl-3H-furan-2-one 
• 99-66-1 valproic acid 
• 108-29-2 5-methyl-dihydro-furan-2-one 
• 200126-81-4 ethyl 5-methyl-2-oxo-3-propyltetrahydrofuran-3-carboxylate 
• 4431-32-7 2,2-di(prop-2-ynyl)propan-1,3-dioic acid 
• 106421-05-0 (+/-)-5-methyl-3-prop-2-ynyl-5H-furan-2-one 
• 3926-76-9 dihydro-5-methyl-3-(2-propenyl)-2(3H)-furanone 

Relevant articles and documents

Synthesis of Lactones via C-H Functionalization of Nonactivated C(sp3)-H Bonds

An electron-deficient amide is utilized as a directing group to functionalize nonactivated C(sp3)-H bonds through radical 1,5-hydrogen abstraction. The γ-bromoamides formed are subsequently converted to γ-lactones under mild conditions. The method described is not limited to tertiary and secondary positions but also allows functionalization of primary nonactivated sp3-hybridized positions in a one-pot sequence. In addition, the broad functional group tolerance renders this method suitable for the late-stage introduction of γ-lactones into complex carbon frameworks.

New syntheses on the basis of ethyl 2-oxotetrahydrofuran-3-carboxylates

Alkylation of 5-substituted ethyl 5-methyl-2-oxotetrahydrofuran-3- carboxylates with alkyl halides in the presence of sodium ethoxide gave the corresponding 3-alkyl derivatives which were converted into 3,5-substituted 5-methyl-N-(4-nitrophenyl)-2-oxotetr