40925-71-1Relevant articles and documents
Production Method of Nitrogen-Containing Fused Ring Compounds
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Page/Page column 67, (2010/11/30)
[Problems] The present invention provides a superior production method and a superior purification method of compounds effective for the treatment or prophylaxis of pathology showing involvement of uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urolithiasis, renal function disorder, coronary artery disease, ischemic heart disease and the like. [Means] A compound represented by the following formula [2] or a pharmaceutically acceptable salt thereof can be produced by reacting a compound represented by the following formula [3] or a salt thereof with a compound represented by the following formula [4], a salt thereof or a reactive derivative thereof. Moreover, crystallization of a compound represented by the formula [2] can be performed with industrially superior workability, and high quality crystals of a compound represented by the formula [2] can be obtained. wherein each symbol is as defined in the description.
Nitrogen-containing fused ring compounds and use thereof
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Page/Page column 104, (2010/11/25)
A URAT1 activity inhibitor containing a nitrogen-containing fused ring compound represented by the following formula [1]: wherein each symbol is as defined in the description. The present invention is useful for the prophylaxis or treatment of pathology showing involvement of uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urolithiasis, renal function disorder, coronary artery disease, ischemic heart disease and the like.
Substituted benzoxazinorifamycin derivative and antibacterial agent containing the same
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, (2008/06/13)
A rifamycin derivative having the formula (I): STR1 wherein R1 is hydrogen atom, methyl group or ethyl group, R2 is an alkyl group having 1 to 4 carbon atoms, and A is a group having the formula: STR2 in which n is an integer of 3 to