40926-74-7

Usage

Uses

Used in Organic Synthesis:
(2,3-dimethylphenoxy)acetyl chloride is used as a reagent for introducing the (2,3-dimethylphenoxy)acetyl group into molecules, which is crucial for the synthesis of various organic compounds.
Used in Pharmaceutical Production:
(2,3-dimethylphenoxy)acetyl chloride is used as an intermediate in the production of pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Agrochemical Production:
(2,3-dimethylphenoxy)acetyl chloride is used as a component in the synthesis of agrochemicals, aiding in the creation of products for agricultural applications.
Used in the Production of Fine Chemicals:
(2,3-dimethylphenoxy)acetyl chloride is utilized in the production of other fine chemicals, where its specific properties are leveraged to create high-quality specialty products.
Safety Note:
It is important to handle (2,3-dimethylphenoxy)acetyl chloride with care, as it can be corrosive and harmful if not handled properly. Proper safety measures should be taken during its use to ensure the well-being of individuals and the environment.

Upstream product

• 2935-63-9 (2,3-dimethylphenoxy)acetic acid 

Downstream Products

• 120680-73-1 2-[2-(2,3-Dimethyl-phenoxy)-acetylamino]-3-phenyl-propionic acid 
• 1357284-99-1 O,O'-dibutyl {[2-(2,3-dimethylphenoxy)acetamido](4-methoxyphenyl)methyl}phosphonate 
• 35370-84-4 2-(2,3-dimethylphenoxy)ethanethioamide 
• 1370248-24-0 2-[2,3-dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole 
• 1370243-82-5 2-[2,3-dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole 
• 1370243-80-3 2-[2,3-dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole 
• 1370243-78-9 2-[2,3-dimethyl-4-(2-methylene-1-oxobutyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole 
• 1370243-76-7 2-[2,3-dimethyl-4-(2-methylene-1-oxobutyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole 
• 1370243-74-5 2-[2,3-dimethyl-4-(2-methylene-1-oxobutyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole 
• 1370243-68-7 2-[2,3-dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-phenylthiazole 
• 1370244-19-1 2-[2,3-dimethyl-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole 
• 1370244-17-9 2-[2,3-dimethyl-4-(1-oxopropyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole 
• 1370244-15-7 2-[2,3-dimethyl-4-(1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole 

Relevant academic research and scientific papers

Synthesis and anticonvulsant activity of phenoxyacetyl derivatives of amines, including aminoalkanols and amino acids

A series of 17 new phenoxyacetamides has been prepared via multistep chemical synthesis as a continuation of the research carried out by our group on di- and tri-substituted phenoxyalkyl and phenoxyacetyl derivatives of amines. The obtained compounds vary in an amide component, for example aminoalkanol or (un)modified amino acid moieties were introduced. The structures of selected products were confirmed by means of crystallographic methods. All 17 compounds were the subject of preliminary screening for potential anticonvulsant activity (MES, 6 Hz and/or scMET tests) and neurotoxicity (rotarod) in mice after intraperitoneal administration, while several active compounds were subsequently examined in additional models (e.g. MES and rotarod-rats, p.o. or i.p., hippocampal kindling-rats, i.p.). Finally, safety studies (cytotoxicity and cell proliferation assays on astrocytes, metabolic stability assessment, mutagenicity evaluation) were performed for several active compounds, including the most promising one (R-(?)-2-(2,6-dimethylphenoxy)-N-(1-hydroxypropan-2-yl)acetamide, MES ED50 = 12.00 mg per kg b.w., rats, p.o.).

Synthesis and Biological Activity of 4-[(Substituted Phenoxyacetoxy)methyl]-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane-1-one

A series of novel 4-[(substituted phenoxyacetoxy)methyl]-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane-1-one 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m, 4n, 4o were synthesized. Their structures were confirmed by IR,1H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, the title compounds 4b, 4c, 4f, 4h, 4i, and 4j possess 90–100% inhibition against the growth of roots of both rape and barnyard grass at 10 mg/L. Moreover, the title compounds 4f, 4g, and 4h possess 75–89% inhibition against Botrytis cinerea at the concentration of 50 mg/L.

Synthesis and Biological Activity of Ethyl 4-Alkyl-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylate

(Chemical Equation Presented) A series of novel ethyl 4-(methyl or trifluoromethyl)-2-(2-(substituted phenoxy)acetamido)thiazole-5-carboxylates 7a, 7b, 7c, 7d, 7e and 8f, 8g, 8h, 8i, 8j, 8k, 8l, 8m, 8n, 8o, 8p, 8q, 8r were synthesized, and their structures were confirmed by IR, 1H-NMR, MS spectra and elemental analysis. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal activities. Compared with the fluorine free compounds 7a, 7b, and 7e, the compounds bearing fluorine 8g, 8j, and 8q showed higher herbicidal activities with 70-100% inhibition against Capsella bursa-pastoris, Amaranthus restroflexus, and Eclipta prostrata at the dosage of 150 g/ha, which indicated that the trifluoromethyl on the thiazole ring was beneficial for the herbicidal activity. Furthermore, compounds 8f, 8g, 8h, 8i, 8j, 8k, 8l, 8m, 8n, 8o, 8p, 8q, 8r were tested for fungicidal activity against Pseudoperonospora cubensis at 500 μg/mL. Compounds 8f and 8q showed the best fungicidal activity with more than 80% inhibition.

The synthesis of ethacrynic acid thiazole derivatives as glutathione S-transferase pi inhibitors

Glutathione S-transferase pi (GSTpi) is a phase II enzyme which protects cells from death and detoxifies chemotherapeutic agents in cancer cells. Ethacrynic acid (EA) is a weak GSTpi inhibitor. Structure modifications were done to improve the ability of EA to inhibit GSTpi activity. Eighteen EA thiazole derivatives were designed and synthesized. Compounds 9a, 9b and 9c with a replacement of carboxyl group of EA by a heterocyclic thiazole exhibited improvement over EA to inhibit GSTpi activity.

Studies of O,O-Dimethyl α-(2,4-Dichlorophenoxyacetoxy) ethylphosphonate (HW02) as a new herbicide. 1. Synthesis and herbicidal activity of HW02 and analogues as novel inhibitors of pyruvate dehydrogenase complex

On the basis of the previous work for optimization of O,O-diethyl α-(substituted phenoxyacetoxy)alkylphosphonates, further extensive syntheticmodifications were made to the substituents in alkylphosphonate and phenoxymoieties of the title compounds. New O,O-dimethyl α-(substituted phenoxyacetoxy)alkylphosphonates were synthesized as potential inhibitors of pyruvate dehydorogenase complex (PDHc). Their herbicidal activity and efficacy in vitro against PDHc were examined. Some of these compounds exhibited significant herbicidal activity and were demonstrated to be effective inhibitors of PDHc from three different plants. The structure-activity relationships of these compounds including previously reported analogous compoundswere studied by examining their herbicidal activities. Both inhibitory potency against PDHc and herbicidal activity of title compounds could be increased greatly by optimizing substituent groups of the title compounds. O,O-Dimethyl α-(2,4- dichlorophenoxyacetoxy)ethylphosphonate (I-5), which acted as a competitive inhibitor of PDHc with much higher inhibitory potency against PDHc from Pisum sativum and Phaseolus radiatus than from Oryza sativa, was found to be themost effective compound against broadleaf weeds and showed potential utility as herbicide.

Synthesis of analogs of juvenile hormons proceeding from phenol derivatives

New potential juvenoids, esters of alkenoic and alkadienoic acids with phenoxy-and phenoxy-phenoxyethanol were synthesized, and also esters of phenoxyacetic acid with alkenols amd alkadienols.