40929-50-8

Usage

Synthesis Reference(s)

Synthetic Communications, 24, p. 253, 1994 DOI: 10.1080/00397919408013824Tetrahedron Letters, 25, p. 5939, 1984 DOI: 10.1016/S0040-4039(01)81726-3

InChI:InChI=1/C7H8N2O2/c1-2-11-7(10)6-3-8-5-9-4-6/h3-5H,2H2,1H3

Upstream product

• 4595-59-9 5-bromopyrimidine 
• 623-49-4 ethyl cyanoformate 
• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 

Downstream Products

• 25193-95-7 5-(hydroxymethyl)pyrimidine 
• 4595-61-3 pyrimidine-5-carboxylic acid 
• 144164-23-8 carbonic acid 4-nitro-phenyl ester pyrimidin-5-ylmethyl ester 
• 620533-94-0 3-oxo-3-pyrimidin-5-yl-propionic acid methyl ester 
• 40805-79-6 pyrimidine-5-carbonitrile 
• 887408-29-9 4-isopropylpyrimidine-5-carboxylic acid ethyl ester 
• 954226-53-0 ethyl 2-isopropylpyrimidine-5-carboxylate 
• 90993-50-3 1,3-pyrimidinyl-5-amidoxim 
• 1073460-97-5 2-fluoro-N,N-dimethyl-4-(3-(pyrimidin-5-yl)-1,2,4-oxadiazol-5-yl)aniline 
• 1073460-95-3 5-(2,3-difluorophenyl)-3-(pyrimidin-5-yl)-1,2,4-oxadiazole 
• 40929-42-8 pyrimidine-5-carbohydrazide 
• 1609735-10-5 ethyl 4-(1-cyanocyclohexyl)pyrimidine-5-carboxylate 
• 1401223-30-0 N-isopropyl-2-(4-propylphenoxy)-N-((3-(pyrimidin-5-yl)-1,2,4-oxadiazol-5-yl)methyl)acetamide 
• 1425194-07-5 ethyl 4-(4-(ethoxycarbonyl)phenyl)pyrimidine-5-carboxylate 

Relevant academic research and scientific papers

MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN

There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.

MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS

There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of kallikrein, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of kallikrein.

MULTISUBSTITUTED AROMATIC COMPOUNDS AS INHIBITORS OF THROMBIN

There are provided inter alia multisubstituted aromatic compounds useful for the inhibition of thrombin, which compounds include substituted pyrazolyl or substituted triazolyl. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing a disease or disorder, which disease or disorder is amenable to treatment or prevention by the inhibition of thrombin.

One-pot synthesis of pyrimidine-5-carboxaldehyde and ethyl pyrimidine -5- carboxylate by utilizing pyrimidin-5-yl-lithium

Pyrimidine-5-carboxaldehyde was prepared in a one-pot reaction from 5- bromo-pyrimidine via metal halogen exchange. Pyrimidin-5-yl-lithium reacted with formate ester and ethyl cyanoformate, forming respectively the aldehyde and carboxy ethyl ester.

PALLADIUM CATALYSED SYNTHESIS OF N AND S HETEROCYCLIC ESTERS

Palladium catalysed alkoxycarbonylation of heterocyclic halides affords a simple and versatile synthesis of both N and S heterocyclic esters where a range of catalysts have been studied and a method to employ inexpensive inorganic bases has been found.