4093-60-1

Usage

InChI:InChI=1/C12H14N4O6/c1-3-22-12(17)6-8(2)13-14-10-5-4-9(15(18)19)7-11(10)16(20)21/h4-5,7,14H,3,6H2,1-2H3/b13-8-

Upstream product

• 6127-93-1 3-chlorocrotonic acid ethyl ester 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 584-48-5 2,4-dinitrobromobenzene 
• 141-97-9 ethyl acetoacetate 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 
• 76163-66-1 β-triethylsiloxycrotonic acid ethyl ester 

Downstream Products

• 4343-73-1 ethyl 5-methyl-1H-1,2,3-triazole-4-carboxylate 
• 1567-89-1 N-(2,4-dinitrophenyl)-N'-isopropylidene-hydrazine 
• 1335046-31-5 C₁₆H₁₀N₇O₁₁S^(1-)*Na⁽¹⁺⁾ 
• 98360-51-1 ethyl 3,5-dimethyl-1-(2,4-dinitrophenyl)-1,4,4a,5,10,10a-hexahydropyridazino<3,4-b>quinoxaline-4-carboxylate 

Relevant academic research and scientific papers

Unusual cleavage of n-n bond of 1-arylamino-1,2,3-triazole derivatives: A simple and alternate approach to 4,5-disubstituted-1H-1,2,3-triazoles

In this communication, the authors described the synthesis of 1-arylamino-1,2,3-triazole derivatives via diazo transfer reaction on active methylene hydrazones. Further, we have observed the reduction of 1-arylamino-1,2,3-triazole using Pd/C, H2 to result in unusual N-N bond cleavage to give 4,5-disubstituted-1H-1,2,3-triazole.

Application of Fe3O4@SiO2@sulfamic acid magnetic nanoparticles as recyclable heterogeneous catalyst for the synthesis of imine and pyrazole derivatives in aqueous medium

Sulfamic acid supported on Fe3O4@SiO2 superpara magnetic nanoparticles was successfully applied as a recyclable solid acid catalyst with a large density of sulfamic acid groups for the synthesis of pyrazole derivatives, an important class of potentially bioactive compounds. The products are obtained in high yield from the one-pot reaction procedure involving dicarbonyl compounds and hydrazines/hydrazides. This new method totally avoids the use of toxic or expensive solvents and organic acids in this reaction.

Cellulose sulfuric acid as a bio-supported and efficient solid acid catalyst for synthesis of pyrazoles in aqueous medium

A convenient and practical method was described for the regioselective synthesis of pyrazoles from hydrazines/hydrazides and 1,3-dicarbonyl compounds via the Knorr synthesis in water with cellulose sulfuric acid (CSA) as a biopolymer-based solid acid catalyst. Various hydrazines and hydrazides were reacted with 1,3 diketones and the desired pyrazoles were obtained in high yields. The reaction of less reactive hydrazines with 1,3-dicarbonyl compounds stopped at the corresponding hydrazone derivatives. Hydrazides were employed with β-ketoester, and imine adducts were the only isolated product. Simple isolation of products, mild reaction conditions, reusability of solid acid catalysts and short reaction times are advantages of this green procedure. This journal is

PEG-SO3H as a mild, efficient and green catalytic system for the synthesis of pyrazole derivatives in aqueous medium

A versatile, alternative and environmentally benign strategy for the synthesis of a series of pyrazoles has been successfully performed in water using PEG-SO3H as an acidic catalyst. The products are obtained in high yield from the one-pot reaction procedure involving dicarbonyl compounds and hydrazines/hydrazides. This new method totally avoids the use of organic acids and toxic or expensive solvents in this reaction. The catalyst is waste-free, easily prepared, and efficiently re-used.

Synthesis of 1-aryl(hetaryl)pyrazol-5-ols and azopyrazoles on their basis

Treatment of 3,5-dichloropyrid-2-ylhydrazine, and of mono- and dinitrophenylhydrazines with acetoacetic ester gave hydrazones and the products of their cyclization, namely pyrazolols. It was shown that acetoacetic ester 2,4-dinitrophenylhydrazone cyclizes