Cas 40930-12-9,4H-Pyrrolo[1,2-c][1,2,3]triazole, 5,6-dihydro-3-phenyl-

40930-12-9

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Basic information

Product Name: 4H-Pyrrolo[1,2-c][1,2,3]triazole, 5,6-dihydro-3-phenyl-
Synonyms:
CAS NO:40930-12-9
Molecular Formula: C11H11N3
Molecular Weight: 185.228
EINECS: N/A
Product Categories: N/A
Mol File: 40930-12-9.mol

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 4H-Pyrrolo[1,2-c][1,2,3]triazole, 5,6-dihydro-3-phenyl-(CAS DataBase Reference)
NIST Chemistry Reference: 4H-Pyrrolo[1,2-c][1,2,3]triazole, 5,6-dihydro-3-phenyl-(40930-12-9)
EPA Substance Registry System: 4H-Pyrrolo[1,2-c][1,2,3]triazole, 5,6-dihydro-3-phenyl-(40930-12-9)

Safety Data

Hazard Codes: N/A
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Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
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Hazardous Substances Data: 40930-12-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 40930-12-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,9,3 and 0 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 40930-12:
(7*4)+(6*0)+(5*9)+(4*3)+(3*0)+(2*1)+(1*2)=89
89 % 10 = 9
So 40930-12-9 is a valid CAS Registry Number.

40930-12-9Upstream product

40930-12-9Downstream Products

40930-12-9Relevant academic research and scientific papers

SYNTHESIS AND ANTIPHOTOAGING ACTIVITY OF NOVEL 3-PED4HPT DERIVATIVES

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Page/Page column 7; 8; 9, (2018/08/19)

Disclosed herein are a pharmaceutical composition for treating the premature aging of skin (photoaging) and including a triazole derivative of formula I, as well as the preparation method of the derivative of formula I. The method is performed by reacting a starting material of formula II with ZnCl2 to afford the derivative of formula I. Each of R1, R2 and R3 in formulas I and II may be the moiety, such as -H, -X, -CH3, -C2H5, -NO2, -OCH3, -NH2 and -CX3, and n denotes to 1 or 2. Derivatives of formula I can suppress UVA-induced damage in fibroblasts, decrease the levels of ROS, MMP-1 and/or SA-β-Gal, and/or increase the levels of ATP, mitochondrial membrane potential, TIMP-1 and/or COL1α1 in fibroblasts. Therefore, derivatives of formula I have the potential in the treatment, therapy and improvement on photoaging, and can be applied in industries, such as medical treatment, medical cosmetics, beauty, skin care, skin recuperation, cosmetics and color cosmetics, for example.

Discovery, synthetic methodology, and biological evaluation for antiphotoaging activity of bicyclic[1,2,3]triazoles: In vitro and in vivo studies

Hsieh, Hsin-Yu,Lee, Wen-Chun,Senadi, Gopal Chandru,Hu, Wan-Ping,Liang, Jium-Jia,Tsai, Tong-Rong,Chou, Yu-Wei,Kuo, Kung-Kai,Chen, Chung-Yu,Wang, Jeh-Jeng

, p. 5422 - 5435 (2013/07/26)

Novel bicyclic[1,2,3]triazoles (4, 7, 11, 15) have been synthesized using a one-pot metal free strategy with high structural diversity as photoprotective agents, and their effect on UVA-induced senescence in human dermal fibroblast cells (FB) and the asso

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