409319-69-3Relevant academic research and scientific papers
A new and convenient method for the preparation of cyclooctanone containing bis-aldol skeleton by samarium(II) iodide-mediated intramolecular aldol cyclization of ω-oxiranyl keto octanal
Pudhom, Khanitha,Arai, Hidehiro,Yamane, Keiko,Mukaiyama, Teruaki
, p. 82 - 83 (2002)
A polyoxy eight-membered ring compound containing a bisaldol skeleton, 2,6-dibenzyloxy-3-(t-butyldimethylsiloxy)-7-hydroxy-8-hydroxymethyl-5- (p-methoxybenzyloxy)-4,4-dimethyl-cyclooctanone 1, a key synthetic intermediate of 19-hydroxypaclitaxel, was prep
Convenient methods for the preparation of unsymmetrical double aldols
Mukaiyama, Teruaki,Pudhom, Khanitha,Yamane, Keiko,Arai, Hidehiro
, p. 413 - 425 (2007/10/03)
Double aldol reaction proceeded stereoselectively at one α-carbon of ketones to give α-(1-hydroxyalkyl)-β-hydroxyalkyl ketones (double aldols) in good to high yields by the following three methods: i) tin(II) trifluoromethanesulfonate-mediated aldol reaction of aldehydes with β-hydroxy ketones (mono-aldols) in the presence of tertiary amines, ii) samarium(II) iodide-mediated aldol reaction of aldehydes with alkyl or aryl oxiranyl ketones, iii) Sn(OTf)2- promoted aldol reaction of α-bromo ketones with aldehydes giving α-bromo-β-stannyloxy ketones which were then converted to titanium enolates on treatment with low-valent titanium. Double aldols were formed by subsequent reaction of the above titanium enolates with aldehydes in one-pot procedure. Further, small and medium-sized carbocyclic compounds whose ring skeletons were composed of double aldol structure were synthesized by SmI2-mediated intramolecular cyclization between oxiranyl ketone and aldehyde functions.
