409366-62-7

Basic information

• Product Name: 2,3,6-trimethyl-{[(2E)-3-phenylprop-2-en-1-yl]oxy}phenyl acetate
• Synonyms: 2,3,6-trimethyl-{[(2E)-3-phenylprop-2-en-1-yl]oxy}phenyl acetate
• CAS NO: 409366-62-7
• Molecular Weight: 310.393
• Mol File: 409366-62-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,3,6-trimethyl-{[(2E)-3-phenylprop-2-en-1-yl]oxy}phenyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,6-trimethyl-{[(2E)-3-phenylprop-2-en-1-yl]oxy}phenyl acetate(409366-62-7)
• EPA Substance Registry System: 2,3,6-trimethyl-{[(2E)-3-phenylprop-2-en-1-yl]oxy}phenyl acetate(409366-62-7)

Safety Data

• Hazardous Substances Data: 409366-62-7(Hazardous Substances Data)

Upstream product

• 36592-62-8 4-acetoxy-2,3,5-trimethylphenol 
• 4392-24-9 Cinnamyl bromide 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 

Downstream Products

• 216989-58-1 4-hydroxy-2,3,6-trimethyl-5-(1-phenyl-2-propenyl)phenyl acetate 

Relevant articles and documents

A new route to vitamin E Key-intermediates by olefin cross-metathesis

Ru-Catalyzed olefin cross-metathesis (CM) has been successfully applied to the synthesis of several phytyl derivatives (2b, 2d-f, 3b) with a trisubstituted C=C bond, as useful intermediates for an alternative route to α-tocopheryl acetate (vitamin E acetate; 1b) (Scheme 1). Using the second-generation Grubbs catalyst RuCl2(C21H 26N2)(CHPh)PCy3, (Cy = cyclohexyl; 4a) and Hoveyda-Grubbs catalyst RuCl2(C21H26N 2){CH-C6H4(O-iPr)-2} (4b), the reactions were performed with various C-allyl (5a-f, 7a,b) and O-allyl (8a-d) derivatives of trimethylhydroquinone-1-acetate as substrates. 2,6,10,14-Tetramethylpentadec-1-ene (6a) and derivatives 6c-e of phytol (6b) as well as phytal (6f) were employed as olefin partners for the CM reactions (Schemes 2 and 5). The vitamin E precursors could be prepared in up to 83% isolated yield as (E/Z)-mixtures.