40940-48-5Relevant academic research and scientific papers
(Z)-Ethyl 2-phenyl-1-(2-vinylphenyl)vinylcarbamates. Part 1: Synthesis and preliminary studies on their divergent transformation into benzo[c] phenanthridines and 2-phenyl-1,4-naphthoquinones
Treus, Mónica,Salas, Cristian O.,Gonazález, Marcos A.,Estévez, Juan C.,Tapia, Ricardo A.,Estévez, Ramón J.
experimental part, p. 9986 - 9995 (2011/02/23)
Treatment of N-carbethoxy-1-benzylideneisoquinolines with LDA gives N-ethoxycarbonyl-1-amino-1-(2-vinylphenyl)-2-phenylethylenes, which can easily be transformed into N-carbethoxy-1-amino-2-phenylnaphthalenes. Bischler-Napieralski reaction of these latter
From phenylacetylphenylacetic acids and 1-benzylisoquinolines to 6,11-dihydrobenzo[b]naphtho[2,3-d]furan-6,11-diones, 6H-dibenzo[c,h]chroman-6-ones and 7,12-dihydro-5H-dibenzo[c,g]chroman-5,7,12-triones via 2-phenyl-3-hydroxy-1,4-dihydro-1,4-naphthalenediones or 2-phenyl-1-naphthols
Martínez, Elena,Martínez, Luis,Treus, Mónica,Estévez, Juan C.,Estévez, Ramón J.,Castedo, Luis
, p. 6023 - 6030 (2007/10/03)
We describe the synthesis of 6,11-dihydrobenzo[b]naphtho[2,3-d]furane-6,11-diones, 6H-Dibenzo[c,h]chroman-6-ones and 7,12-dihydro-5H-dibenzo[c,g]chroman-5,7,12-triones from 2-(2'-phenyl)-3-hydroxy-1,4-dihydro-1,4-naphthalenediones or 2-phenyl-1-naphthols obtained from 2-(2'-bromophenylacetyl)-phenylacetic acids or 1-benzylisoquinolines. (C) 2000 Elsevier Science Ltd.
A novel C-N cleavage in isoquinolines allowing the first direct transformation of 1-benzylisoquinolines into benzo[c]phenanthridines and a new route to 2-phenyl-1,4-naphthoquinones
Treus,Estevez,Castedo,Estevez
, p. 6351 - 6353 (2007/10/03)
Treatment of N-carbethoxy-1-benzylideneisoquinolines with LDA gives N-ethoxycarbonyl-1-amino-1-(2-vinylphenyl)-2-phenylethylenes, which can easily be transformed into N-carbethoxy-1-amino-2-phenyl-naphthalenes. Bichler-Napieralski reaction of these latter compounds affords the corresponding benzo[c]-phenanthridines, while their hydrolysis and subsequent oxidation constitutes a route to 2-phenyl-1,4-naphthoquinones. (C) 2000 Elsevier Science Ltd.
BENZOPHENANTHRADINES. VII. SYNTHESIS OF BENZOPHENANTHRIDINES WITH A QUINONOID RING C. 5-METHYL- AND 5,6-DIMETHYL-5-HYDROXY-2,3,9,10-TETRAMETHOXY-5,6-DIHYDROBENZOPHENANTHRIDINE-7-12-DIONES
Sladkov, V. I.,Medzhitov, D. R.,Khokhlov, V. A.,Suvorov, N. N.
, p. 774 - 779 (2007/10/02)
Representatives of a new type of quinonoid benzophenanthradine, i.e., 6-methyl- and 5,6-dimethyl-5-hydroxy-2,3,9,10-tetramethoxy-5,6-dihydrobenzophenanthridine-7,12-diones, were synthesized from 6,7-dimethoxy-3-(3,4-dimethoxyphenyl)-2-methylamino-1,
BENZOPHENANTHRIDINES. II. CONSTRUCTION OF THE ACD FRAGMENTS IN THE TOTAL SYNTHESIS OF BENZO- AND BENZOPHENANTHRIDINES BY ALKYLATION OF THE SILVER SALT OF 2-HYDROXY-6,7-DIMETHOXY-3-(3,4-DIMETHOXYPHENYL)-1,4-NAPHTHOQUINONE
Khokhlov, V. A.,Sladkov, V. I.,Kurkovskaya, L. N.,Kuleshova, E. F.,Anisimova, O. S.,Suvorov, N. N.
, p. 976 - 983 (2007/10/02)
The alkylation of the silver salt of 2-hydroxy-6,7-dimethoxy-3-(3,4-dimethoxyphenyl)-1,4-naphthoquinone by methyl, ethyl, butyl, or isopropyl halides leads to the formation of a mixture of isomeric 2-alkoxy-1,4- and 4-alkoxy-1,2-naphthoquinones.The isomer
BENZOPHENANTHRIDINES. I. SYNTHESIS OF 7,12-DIACETOXY-2,3,9,10-TETRAMETHOXY-5,6-DIMETHYLBENZOPHENANTHRIDINIUM PERCHLORATE
Khokhlov, V. A.,Sladkov, V. I.,Kurkovskaya, L. N.,Kuleshova, E. F.,Suvorov, N. N.
, p. 538 - 543 (2007/10/02)
The synthesis of a structural isomer of the highly active antileukemia benzophenathridine alkaloids, i.e., 7,12-diacetoxy-2,3,9,10-tetramethoxy-5,6-dimethylbenzophenanthridinium perchlorate, was realized from 2-hydroxy-3-(3,4-dimethoxyphenyl)-6,7-di
BENZOPHENANTHRIDINES. IV. SYNTHESIS OF THE BENZOPHENANTHRIDINE RING FROM ETHYL 6-(3,4-DIMETHOXYPHENYLACETYL)-3,4-DIMETHOXYPHENYLACETATE. 11,12-DIACETOXY-6-METHYLFAGARONINE METHYL ESTER PERCHLORATE
Khokhlov, V. A.,Sladkov, V. I.,Kuleshova, L. N.,Suvorov, N. N.
, p. 2379 - 2384 (2007/10/02)
The perchlorate of 11,12-diacetoxy-6-methylfagaronine methyl ester was synthesized from ethyl 6-(3,4-dimethoxyphenylacetyl)-3,4-dimethoxyphenylacetate through the formation of the corresponding 2-hydroxy-1,4- and then the 4-isopropyloxy-1,2-naphthaquinone
