40941-09-1Relevant academic research and scientific papers
Phosphine-free palladium catalytic system for the selective direct arylation of furans or thiophenes bearing alkenes and inhibition of heck-type reaction
Chen, Lu,Roger, Julien,Bruneau, Christian,Dixneuf, Pierre H.,Doucet, Henri
supporting information; experimental part, p. 2749 - 2760 (2011/12/02)
Palladium acetate associated to potassium carbonate as catalytic system has been found to efficiently catalyse the direct 5-arylation of furans or thiophenes bearing enal, enone or acrylate functions at carbon C-2, and to inhibit the Heck-type reaction. The nature of the base is crucial to control the selectivity of the arylation. In the presence of electron-deficient aryl bromides and potassium carbonate as the base, the direct arylation is favoured, whereas the use of potassium fluoride gave selectively the Heck-type product, and tri-n-butylamine the reductive addition product. Copyright
