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2,4(1H,3H)-Pyrimidinedione, 5,6-diamino-3-methyl-, also known as trimethoprim, is a synthetic antibacterial agent that belongs to the dihydrofolate reductase inhibitors class of medications. It is commonly used in combination with sulfamethoxazole to treat a variety of bacterial infections, including urinary tract infections, respiratory infections, and certain types of pneumonia. Trimethoprim works by inhibiting the enzyme dihydrofolate reductase, which is essential for the synthesis of DNA and RNA in bacteria, leading to the disruption of bacterial growth and replication.

40959-24-8

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40959-24-8 Usage

Uses

Used in Pharmaceutical Industry:
Trimethoprim is used as an antibacterial agent for the treatment of various bacterial infections. It is particularly effective against urinary tract infections, respiratory infections, and certain types of pneumonia. The reason for its use in this industry is its ability to inhibit the enzyme dihydrofolate reductase, which is crucial for bacterial DNA and RNA synthesis, thereby disrupting bacterial growth and replication.
Used in Combination Therapy:
Trimethoprim is used in combination with sulfamethoxazole, a sulfonamide antibiotic, to enhance the effectiveness of bacterial infection treatment. This combination therapy helps to target a broader range of bacteria and reduces the likelihood of antibiotic resistance development.
However, it is important to note that trimethoprim is associated with potential side effects, including skin rashes, nausea, and an increased risk of developing antibiotic resistance. Therefore, it should be used under the guidance of a healthcare professional and only when necessary.

Check Digit Verification of cas no

The CAS Registry Mumber 40959-24-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,9,5 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 40959-24:
(7*4)+(6*0)+(5*9)+(4*5)+(3*9)+(2*2)+(1*4)=128
128 % 10 = 8
So 40959-24-8 is a valid CAS Registry Number.

40959-24-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6-diamino-3-methyl-1H-pyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names 5,6-diamino-3-methyl-2,4(1H,3H)-pyrimidinedione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:40959-24-8 SDS

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