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Upstream product

• 554-14-3 2-Methylthiophene 
• 29421-73-6 3,5-dibromo-2-methylthiophene 
• 1369356-10-4 5-bromo-2-methylthiophene-3-carbaldehyde 
• 98-80-6 phenylboronic acid 
• 61285-25-4 3-bromo-2-methyl-5-phenylthiophene 
• 68-12-2 N,N-dimethyl-formamide 

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• 1054613-79-4 1,2-bis(2’-methyl-5’-phenylthien-3’-yl)-2-hydroxy-1-ethanone 

Relevant academic research and scientific papers

A dual-mode visual detector for toxic hydrazine

Hydrazine (N2H4) is one of the commonly used chemical reagents in numerous industries and applications but its toxicity to humans poses a need to develop simple visual detection methods. Herein, we demonstrate a novel dual-mode system to detect and simultaneously consume hydrazine in vapour and solution by using a small photoresponsive molecule that has altered optical response (both colourimetric and fluorescent) after reacting with hydrazine. This journal is

Accelerated Discovery of α-Cyanodiarylethene Photoswitches

Cyanodiarylethene chromophores are able to undergo constitutional exchange via dynamic covalent chemistry (DCC). During this process, the central ethylene bridge of the molecular scaffold can be broken and thereby enables the assembly of a new combination of aryl moieties around the reformed ethylene bridge. The reversible CC double bond exchange has exemplarily been investigated using α-cyanostilbenes. Establishing a dynamic equilibrium reaction from α-cyanodiarylethene with arylacetonitriles under mild conditions has been the basis to access constitutional libraries of new photoswitches with potentially improved properties. When subject to irradiation with light of adequate wavelength, α-cyanodiarylethenes undergo Z/E isomerization followed by ring-closure. By screening the thus accessible dynamic chromophore libraries using a desired detection wavelength, we could identify specific dithienyl analogues that exhibit three-state photochromism. The combination of dynamic constitutional libraries of functional chromophores in combination with the light-guided screening and selection should lead to more rapid exploration of structural diversity dye chemistry.

Modulating the Lewis acidity of boron using a photoswitch

(Chemical Equation Presented). Light turns the Lewis acid on: The Lewis acidity of a boron atom integrated into a cyclic dithienylethene photoswitch is modulated by light: 1a has low Lewis acidity since the p orbital of the boron center is partially occupied by delocalized π electrons, whereas the rearrangement of the p electrons in 1b reduces the electron density at the boron center and turns the Lewis acid on .

Heterocyclic derivatives in the treatment of Ischaemia and related diseases

Compounds of the formula: STR1 wherein A, R1, R2, R3 and m are defined as in the specification or a pharmaceutically acceptable acid addition salt or N-oxide thereof, are calcium and sodium channel antagonists useful for treating mammals having a variety of disease states, such as stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, and also for treatment of spinal injuries.