4099-30-3

Basic information

• Product Name: Desacetylcinobufotalin
• Synonyms: Desacetylcinobufotalin;14,15β-Epoxy-3β,5,16β-trihydroxy-5β-bufa-20,22-dienolide;Deacetylcinobufotalin;De-O-acetylcinobufotalin
• CAS NO: 4099-30-3
• Molecular Formula: C24H32O6
• Molecular Weight: 416.51
• Mol File: 4099-30-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 275-277℃
• Boiling Point: 636.7°C at 760 mmHg
• Flash Point: 220.4°C
• Appearance: /
• Density: 1.37±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 6.9E-19mmHg at 25°C
• Refractive Index: 1.637
• PKA: 14.24±0.70(Predicted)
• CAS DataBase Reference: Desacetylcinobufotalin(CAS DataBase Reference)
• NIST Chemistry Reference: Desacetylcinobufotalin(4099-30-3)
• EPA Substance Registry System: Desacetylcinobufotalin(4099-30-3)

Safety Data

• Hazardous Substances Data: 4099-30-3(Hazardous Substances Data)

Usage

Description

Desacetylcinobufotalin is a bioactive compound derived from the skin secretions of the Chinese red-headed toad (Bufo gargarizans). It possesses potent cytotoxic properties and has been found to be effective against various cancer cell lines.

Uses

Used in Pharmaceutical Industry:
Desacetylcinobufotalin is used as an anticancer agent for its ability to significantly inhibit the growth and induce apoptosis of LM-8 cells, which are a type of leukemia cell line. Its cytotoxic effects make it a promising candidate for the development of new cancer treatments.
Used in Hepatocellular Carcinoma Treatment:
Desacetylcinobufotalin is also used as a cytotoxic agent against HepG2 cells, which are a type of liver cancer cell line. Its effectiveness against these cells suggests potential applications in the treatment of hepatocellular carcinoma, a common form of liver cancer.

InChI:InChI=1/C24H32O6/c1-21-8-5-14(25)11-23(21,28)10-7-16-15(21)6-9-22(2)18(13-3-4-17(26)29-12-13)19(27)20-24(16,22)30-20/h3-4,12,14-16,18-20,25,27-28H,5-11H2,1-2H3/t14-,15?,16?,18-,19+,20+,21+,22+,23-,24+/m0/s1