4099-73-4Relevant academic research and scientific papers
Dinitroalkyl aromatics polymerization retarders or inhibitors and methods for making and for using same
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Example 1, (2008/06/13)
A vinyl monomer inhibitor systems is disclosed which includes 2,6-dinitro-4-alkylated phenols and mixtures of 2,6-dinitro-4-alkylated phenols and 2,4-dinitro-6-alkylated phenols as well as vinyl monomer stabilized composition including an effective amount of the inhibitor systems. A method for the preparation and use is also disclosed where phenol is first alkylated under conditions that afford predominately monoalkylated phenols having a high para alkylation preference, followed by nitration of the alkylated phenols to form a dinitrated, monoalkylated product.
2-OXY-4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS AND PHARMACEUTICAL USE
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, (2008/06/13)
2-Oxy-4H-3,1-benzoxazin-4-ones, useful as serine protease inhibitors, represented by the formula: STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein:a is an integer of 1 to 4;A is a bond, or alkylene having one to ei
2-OXY-4H-3,1-BENZOXAZIN-4-ONES AND PHARMACEUTICAL USE
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, (2008/06/13)
2-Oxy-4H-3,1-benzoxazin-4-ones represented by the formula: STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein: a is an integer of 0-4;A is a bond, or alkylene having one to eight carbon atoms;R is hydrogen, phenyl, imidazolyl or cycloalkyl having three to six carbon atoms, wherein the phenyl, imidazolyl or cycloalkyl ring is optionally substituted with 1-3 substituents independently selected from the group consisting of lower alkyl having one to four carbon atoms, lower alkoxy having one to four carbon atoms,--N(R 1) 2,--NO 2, halo or lower alkylthio having one to four carbon atoms, and, each R' is independently selected from the group consisting of lower alkyl having one to six atoms, lower alkenyl having two to six carbon atoms, lower alkoxy having one to six carbon atoms, lower alkylthio or halo-lower alkyl having one to four carbon atoms, halo,--NO 2,--N(R 1) 2, STR2--NR 1 COR 2, and STR3 in which each R 1 is independently hydrogen or lower alkyl having one to four carbon atoms, or together form a piperidine or a piperazine ring optionally substituted at the ring nitrogen by lower alkyl having one to four carbon atoms or--CH 2 CH 2 OH, each R 2 is independently lower alkyl having one to four carbon atoms, A is an alkylene group if R is hydrogen, and the pharmaceutically acceptable acid addition salts thereof are useful as serine protease inhibitors in humans and animals.
