40991-38-6

Usage

InChI:InChI=1/C8H7NOS/c1-10-8-6-4-2-3-5-7(6)11-9-8/h2-5H,1H3

Upstream product

• 5728-16-5 3-methoxy-4-chloro-1,2,5-thiadiazole 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 2634-33-5 1,2-benzisothiazolin-3-one 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 

Downstream Products

• 33174-74-2 2,2 dithiobis(benzonitrile) 
• 7716-66-7 3-chloro-1,2-benzisothiazole 

Relevant academic research and scientific papers

METHOD FOR PREPARATION OF 2-METHYL-1,2-BENZISOTHIAZOLIN-3-ONE

A method for preparation of 2-methyl-1,2-benzisothiazolin-3-one from 1,2-benzisothiazolin-3-one by contacting 1,2-benzisothiazolin-3-one with an alkali metal hydroxide and dimethyl sulfate.

An Aryne-Based Route to Substituted Benzoisothiazoles

The combination of arynes, generated using fluoride from the corresponding 2-(trimethylsilyl)aryl triflates, and 3-hydroxy-4-aminothiadiazoles leads to the selective formation of 3-amino-substituted benzo[d]isothiazoles. Variation of the substitution pattern of the aryne precursor, and of the thiadiazole, is possible, with the target heterocycles being obtained in good to excellent yields. In all cases, use of 3-hydroxy-4-aminothiadiazoles leads to incorporation of the amino-substituent in the product heterocycle.

Process for preparing benzisothiazolinones

N-alkylated 1,2-benzisothiazolin-3-ones can be prepared in good yield and good selectivity by reaction of the lithium salt of 1,2-benzisothiazolin-3-one with an electrophilic alkylating agent.