410071-83-9

Upstream product

• 463-71-8 thiophosgene 

Downstream Products

• 410072-00-3 methanesulfonic acid 3-isothiocyanato-4-[(Z)-3-(tetrahydropyran-2-yloxy)propenyl]phenyl ester 
• 410072-01-4 2-{1-tert-butoxycarbonyl-6-methanesulfonyloxy-3-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-indol-2-yl}malonic acid benzyl ester methyl ester 
• 410071-85-1 2-{6-methanesulfonyloxy-3-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-indol-2-yl}malonic acid benzyl ester methyl ester 
• 410071-84-0 2-{5-methanesulfonyloxy-2-[(Z)-3-(tetrahydropyran-2-yloxy)propenyl]-phenylthiocarbamoyl}malonic acid benzyl ester methyl ester 
• 287980-11-4 1-[tert-butoxycarbonyl]-3-[2-[[(2,4-dinitrophenyl)sulfonyl][[(2S)-4-ethyl-2,3-dihydro-2-furanyl]methyl]amino]ethyl]-α-methylene-6-[(methanesulfonyl)oxy]-1H-indole-2-acetic acid methyl ester 

Relevant academic research and scientific papers

Intermediates for synthesis of vinblastine compound and method for synthesizing the intermediate

Intermediates A, which are important in the whole synthesis of vindoline; and a method of synthesizing intermediates respectively represented by the general formulae B and C. By the method, the target intermediates are effectively synthesized with satisfactory reproducibility. This synthesis method is especially suitable for mass production. General formula A General formula B General formula C

Stereocontrolled total synthesis of (+)-vinblastine

A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units. Copyright