410085-01-7Relevant academic research and scientific papers
New approaches to the synthesis of spiro-peroxylactones
McCullough, Kevin J.,Tokuhara, Hidekazu,Masuyama, Araki,Nojima, Masatomo
, p. 1522 - 1527 (2007/10/03)
Ozonolysis of (alkenyldioxy)cyclododecyl hydroperoxides in trifluoroethanol gave a separable mixture of the corresponding a-hydroperoxy- and a-hydroxy-substituted spiro-tetraoxacycloalkanes with ring sizes in the range 7-12. Dehydration of the hydroperoxides or oxidation of the hydroxy-compounds afforded the corresponding peroxylactones. The solid-state structure of 1,2,6,7-tetraoxaspiro[7.11]nonadecan-3-one was determined by X-ray crystallographic analysis.
Synthesis and notable antimalarial activity of acyclic peroxides, 1-(alkyldioxy)-1-(methyldioxy)cyclododecanes
Hamada, Yoshiaki,Tokuhara, Hidekazu,Masuyama, Araki,Nojima, Masatomo,Kim, Hye-Sook,Ono, Kanako,Ogura, Naoki,Wataya, Yusuke
, p. 1374 - 1378 (2007/10/03)
Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).
