410098-31-6Relevant academic research and scientific papers
A tin hydride designed to facilitate removal of tin species from products of stannane-mediated radical reactions
Clive, Derrick L. J.,Wang, Jian
, p. 1192 - 1198 (2007/10/03)
The stannane 1, which is simple to prepare, behaves like the conventional reagents Bu3SnH and Ph3SnH in standard free radical reactions, but with the special characteristic that the tin-containing byproducts are easily and very largely removed by mild hydrolysis (LiOH-water-THF or TsOH-water-THF), which converts them into base-soluble (aqueous NaHCO3) materials. The performance of stannane 1 was evaluated for a range of radical reactions involving halides, selenides, Barton-McCombie deoxygenation, and enyne cyclization. In several cases the effectiveness of the workup procedure in removing tin species was monitored by 1H NMR.
