41014-27-1

Basic information

• Product Name: 2-(BROMOMETHYL)BENZOFURAN
• Synonyms: 2-(BROMOMETHYL)BENZOFURAN;2-(broMoMethyl)-1-benzofuran;2-(BroMoMethyl)benzo[b]furan
• CAS NO: 41014-27-1
• Molecular Formula: C₉H₇BrO
• Molecular Weight: 211.06
• Mol File: 41014-27-1.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-(BROMOMETHYL)BENZOFURAN(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(BROMOMETHYL)BENZOFURAN(41014-27-1)
• EPA Substance Registry System: 2-(BROMOMETHYL)BENZOFURAN(41014-27-1)

Safety Data

• Hazardous Substances Data: 41014-27-1(Hazardous Substances Data)

Usage

General Description

2-(Bromomethyl)benzofuran is a chemical compound with the molecular formula C9H7BrO. It is a brominated derivative of benzofuran, which is a heterocyclic compound consisting of a benzene ring fused to a furan ring. The bromomethyl group in 2-(bromomethyl)benzofuran is an alkylating agent that can react with nucleophiles, making it useful in organic synthesis. 2-(BROMOMETHYL)BENZOFURAN has potential applications as a building block in the synthesis of complex organic molecules and pharmaceuticals. It is important to handle 2-(bromomethyl)benzofuran with care, as it is a reactive and potentially hazardous chemical.

Upstream product

• 55038-01-2 benzofuran-2-yl-methanol 
• 3199-61-9 ethyl coumarilate 
• 1646-27-1 methyl benzofuran-2-carboxylate 
• 271-89-6 1-benzofurane 
• 4265-25-2 2-methylbenzofuran 
• 4265-16-1 2-formylbenzo[b]furan 

Downstream Products

• 1254061-88-5 7-(benzofuran-2-ylmethoxy)-1-(2-fluorobenzyl)-4-methyl-1H-[1,2,3]triazolo[4,5-d]pyridazine 
• 1024461-10-6 1-(benzofuran-2-ylmethyl)-4-(4-bromophenyl)piperidin-4-ol 
• 1240407-31-1 1-(benzofuran-2-ylmethyl)-4-(4-iodomophenyl)piperidin-4-ol 
• 1028450-27-2 ethyl 6-[(1-benzofuran-2-ylmethyl)sulfanyl]cyclohex-1-ene-1-carboxylate 
• 121384-03-0 1-[3-(2-benzofurylmethoxy)phenyl]-1-hexanol 
• 104257-02-5 4-{[3-(2-benzofuranylmethoxy)phenyl]amino}-4-oxo-butanoic acid methyl ester 
• 854371-76-9 D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester 
• 854371-75-8 2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenoxymethyl]benzofuran 

Relevant articles and documents

COMPOUND FOR INHIBITING PGE2/EP4 SIGNALING TRANSDUCTION INHIBITING, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF

A compound of formula (I), a preparation method therefor, a pharmaceutical composition containing a derivative thereof, and the therapeutic uses thereof, especially inhibiting PGE2/EP4 signalling transduction and the uses thereof for treating cancer, acute or chronic pain, migraine, osteoarthritis, rheumatoid arthritis, gout, bursitis, ankylosing spondylitis, primary dysmenorrhea, tumour or arteriosclerosis.

Immunomodulator

The invention discloses an immunomodulator, and particularly relates to a compound shown as a formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Experiments prove that the compound has good IL-17A inhibitory activity, can be used for preparing an IL-17A inhibitor and drugs for preventing and/or treating IL-17A mediated diseases (such as inflammation, autoimmune diseases, infectious diseases, cancers and precancerous syndromes), and provides a new medical possibility for clinical treatment of diseases related to abnormal IL-17A activity.

Synthesis and Insecticidal Activity of Spinosyns with C9- O -Benzyl Bioisosteres in Place of the 2′,3′,4′-Tri- O -methyl Rhamnose

The spinosyns are fermentation-derived natural products active against a wide range of insect pests. They are structurally complex, consisting of two sugars (forosamine and rhamnose) coupled to a macrocyclic tetracycle. Removal of the rhamnose sugar results in a >100-fold reduction in insecticidal activity. C9-O-benzyl analogues of spinosyn D were synthesized to determine if the 2′,3′,4′-tri-O-methyl rhamnose moiety could be replaced with a simpler, synthetic bioisostere. Insecticidal activity was evaluated against larvae of Spodoptera exigua (beet armyworm) and Helicoverpa zea (corn earworm). Whereas most analogues were far less active than spinosyn D, a few of the C9-O-benzyl analogues, such as 4-CN, 4-Cl, 2-isopropyl, and 3,5-diOMe, were within 3-15 times the activity of spinosyn D for larvae of S. exigua and H. zea. Thus, although not yet quite as effective, synthetic bioisosteres can substitute for the naturally occurring 2′,3′,4′-tri-O-methyl rhamnose moiety.