41014-75-9Relevant articles and documents
Evaluation of β-Aminocarboxylic Acid Derivatives in Hippocampal Excitatory Synaptic Transmission
Oliveira, Daniela R.,Luchez, Cibele V.,Bortolotto, Zuner A.,Fernandes, Jo?o P. S.
, (2017/11/10)
β-Aminocarboxylic acid derivatives (LINS04 series) were screened with the aim to explore their potential functional role in excitatory synaptic transmission in the central nervous system. We used field recordings in rat hippocampal slices to investigate the effects of the LINS04 series on the synaptic transmission at hippocampal CA1 synapses. We found that LINS04008 and LINS04009 increase the size of the evoked field excitatory postsynaptic potential (EPSP) in a dose-dependent manner. The concentration–response curve shows that the efficacy of LINS04008 is highest in the series (EC50 = 91.32 μM; maximum fEPSP 44.97%). The esters LINS04006 and LINS04005 did not affect the synaptic evoked activity. These data provide the first evidence of synaptic activity enhancement by these compounds and the importance of the acidic group to the activity. This set of data may provide direction for a strategic procedure to restore the glutamate synaptic transmission; however, further studies are needed to establish a more complete picture of how these molecules act on the glutamate transmission, which are in our mind for the next steps.
Three naphthalenedisulfonate polymers with imidazole-containing ligands: Synthesis, structure and heterogeneously catalytic performance in reactions of enamination of β-dicarbonyl compounds
Wang, Li,Liu, Jing,Guo, Hui,Deng, Dongsheng,Yao, Tian,Wang, Xingwei,Wang, Xinyi,Wu, Hongli
supporting information, p. 253 - 260 (2015/04/14)
Three new naphthalenedisulfonate polymers, [Cd(2,6-nds)(bib)]n (1), [Cd(1,5-nds)(bib)]n (2), and [Cu(2,6-nds)0.5(tpim)]n (3), have been successfully synthesized by hydrothermal reactions of corresponding metal salts with naphthalenedisulfonate (nds) and imidazole-containing ligands 1,4-bis(imidazol-1-ylmethyl)benzene (bib) and 2,4,5-tri(4-pyridyl)-imidazole (tpim). The structures of these polymers were determined by single crystal X-ray diffraction analysis. Polymers 1 and 2 crystallize in the same space group and have similar cell parameters, and thus show same three-dimensional (3D) framework architecture. Complex 3 has the same 2D layer structure. The photoluminescent properties of the complexes 1 and 2 were investigated. Catalytic tests indicate that complex 3 has chemo-and regio-selective catalytic activity towards enamination of β-ketoesters.
P2W18O62·24H2O as an efficient and recyclable catalyst for the ecofriendly preparation of β-aminocrotonates
Sanchez, Laura M.,Sathicq, Angel G.,Baronetti, Graciela T.,Thomas, Horacio J.,Romanelli, Gustavo P.
, p. 137 - 142 (2013/06/05)
H6P2W18O62·24H 2O bulk-and silica-supported catalysts were found to be efficient and recyclable catalysts for the synthesis of a series of β-aminocrotonates using toluene as the solvent or under no solvent reaction conditions. Several substituted β-aminocrotonates can be prepared in very good yields and purity by direct reaction of amines and 1,3-dicarbonyl compounds in the presence of a catalytic amount of bulk-and silica-gel-supported H6P 2W18O62·24H2O. The title compounds were prepared in very good yields using both methodologies, and no secondary products were detected. The procedure using no reaction solvent resulted in a clean and useful alternative, which has the advantages of a greener methodology with operative simplicity, the use of a reusable and noncorrosive solid catalyst, soft reaction conditions, low reaction times, and good yields.
