41053-71-8

Basic information

• Product Name: 3-(4-Isobutyl-phenyl)-propionyl chloride
• Synonyms: 3-(4-Isobutyl-phenyl)-propionyl chloride
• CAS NO: 41053-71-8
• Molecular Weight: 224.73
• Mol File: 41053-71-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-Isobutyl-phenyl)-propionyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Isobutyl-phenyl)-propionyl chloride(41053-71-8)
• EPA Substance Registry System: 3-(4-Isobutyl-phenyl)-propionyl chloride(41053-71-8)

Safety Data

• Hazardous Substances Data: 41053-71-8(Hazardous Substances Data)

Upstream product

• 66734-95-0 4-isobutylcinnamic acid 
• 110319-85-2 (4-isobutyl-phenyl)-methanol 
• 38861-88-0 4-isobutylbenzoic acid 
• 38861-78-8 1-(4-isobutyl-phenyl)-ethanone 
• 40150-98-9 4-(2-methyl-1-propyl)benzaldehyde 
• 65322-85-2 3-(4'-isobutylphenyl)propionic acid 

Downstream Products

• 1408237-75-1 N-(4'-hydroxy-3'-methyl-1'-naphthyl)-3-(4-iso-butylphenyl)-propanamide 
• 1408237-73-9 N-(4'-hydroxy-3',5'-dimethylphenyl)-3-(4-iso-butylphenyl)-propanamide 

Relevant articles and documents

In Vivo Characterization of Hydroxamic Acid Inhibitors of 5-Lipoxygenase

The hydroxamic acid functionality can be incorporated into simple molecules to produce potent inhibitors of 5-lipoxygenase.The ability of many of these hydroxamates to inhibit leukotriene synthesis in vivo has been measured directly with a rat peritoneal anaphylaxis model.Despite their potent enzyme inhibitory activity in vitro, many orally dosed hydroxamic acids only weakly inhibited leukotriene synthesis in vivo.This discrepancy is attributable at least in part to the rapid metabolism of hydroxamates to the corresponding carboxylic acids, which are inactive against the enzyme.A study of the structural features that affect this metabolism revealed that 2-arylpropionohydroxamic acids are relatively resistant to metabolic hydrolysis.Several members of this class of hydroxamates are described that are orally active inhibitors of leukotriene synthesis.