410545-57-2

Basic information

• Product Name: Benzonitrile, 4-fluoro-2-(methylthio)-
• CAS NO: 410545-57-2
• Molecular Formula: C8H6FNS
• Molecular Weight: 167.207
• Mol File: 410545-57-2.mol

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-fluoro-2-(methylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-fluoro-2-(methylthio)-(410545-57-2)
• EPA Substance Registry System: Benzonitrile, 4-fluoro-2-(methylthio)-(410545-57-2)

Safety Data

• Hazardous Substances Data: 410545-57-2(Hazardous Substances Data)

Upstream product

• 3939-09-1 2,4-difluorobenzonitrile 
• 5188-07-8 sodium thiomethoxide 
• 463-58-1 carbon oxide sulfide 

Downstream Products

• 410545-58-3 2-methylsulfonyl-4-fluorobenzonitrile 
• 410545-49-2 4-fluoro-2-(methylthio)benzylamine 

Relevant articles and documents

POLAR QUINAZOLINES AS LIVER X RECEPTORS ( LXRS ) MODULATORS

Disclosed are polar quinazoline-based modulators of Liver X receptors (LXRs) and related methods. The modulators include compounds of formula (I): INSERT FORMULA HERE AS IT APPEARS IN WRITTEN FORM IN THE SPECIFICATION (I) in which, R1, R2, R3, R4, R5, R6,

Practical synthesis of 4-fluoro-2-(methylthio)benzylamine and the corresponding sulfone and sulfonamide

Practical syntheses of 4-fluoro-2-(methylthio)benzylamine 1 and the corresponding 2-methylsulfonyl analog 2 are reported. The methylthio moiety was introduced regioselectively by two methods. In the first method, metallation of 4-fluoro-2-bromobenzoic acid, followed by treatment with dimethyl disulfide resulted in an easily isolated intermediate, which was suitable for further elaboration to the benzylamine 1. In the second method, selective nucleophilic aromatic substitution of 2,4-difluorobenzonitrile with methanethiolate was explored, and a mechanistic rationale was offered for solvent effects on regioselectivity. Optimized conditions furnished the key 4-fluoro-2-(methylthio) benzonitrile for further functionalization to the 2-methylsulfonyl-4- fluorobenzylamine 2. In addition, the analogous sulfonamide 3 was prepared in a straightforward manner from 5-fluoro-2-methylbenzenesulfonyl chloride. Copyright Taylor & Francis Group, LLC.

HIV integrase inhibitors: cyclic pyrimidinone compounds

The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses intermediates useful for making the pyrimidone compounds. Additionally, pharmaceutical compositions and methods for treating those infected with HIV are encompassed.

Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors

Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the