4108-07-0Relevant academic research and scientific papers
Impact of Functional Groups on the Copper-Initiated N-Arylation of 5-Functionalized Pyrrolidin-2-ones and Their Vinylogues
Baudelet, Davy,Da?ch, Adam,Rigo, Beno?t,Lipka, Emmanuelle,Gautret, Philippe,Homerin, Germain,Claverie, Christelle,Rousseau, Jolanta,Abuhaie, Cristina-Maria,Ghinet, Alina
, p. 2226 - 2244 (2016/07/15)
The electronic effects governing the N-arylation of pyrrolidone were investigated. The generalization of our preliminary findings on a copper(I)-catalyzed Csp2-N coupling process was first improved with a wide variety of aryl and heteroaryl halides and methyl pyroglutamate. The optimized protocol was further extended to pyrrolidin-2-ones substituted at the C5-position with an aryl group bearing an electron-donating or electron-withdrawing group as well as to some of their substituted enaminoester vinylogues. The impact of substituents at the N- and C5-position on these coupling processes seemed to be pivotal for determining both the reaction profiles and yields.
Studies on pyrrolidinones. Synthesis and reactivity of some N-protected pyroglutamic derivatives
Rigo,Erb,El Ghammarti,Gautret,Couturier
, p. 1599 - 1604 (2007/10/03)
The synthesis of pyroglutamoyl chloride N-protected by a methoxycarbonyl or a trifluoroacetyl group is described. Some aspects of the reactivity of these compounds and intermediates have been studied.
