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(+/-)-19,20-Didehydroyohimbine is a naturally occurring indole alkaloid found in the bark of the Yohimbe tree (Pausinystalia yohimbe), native to Central and Western Africa. It is structurally similar to yohimbine, a well-known aphrodisiac and stimulant, but with a double bond between carbons 19 and 20, which differentiates it from its parent compound. This chemical modification may influence its pharmacological properties, potentially affecting its activity as an alpha-2 adrenergic receptor antagonist, which is the basis for its use in treating erectile dysfunction and as a stimulant. However, it is important to note that (+/-)-19,20-didehydroyohimbine is less studied than yohimbine, and its effects and safety profile are not as well established.

4109-62-0

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4109-62-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4109-62-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,0 and 9 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4109-62:
(6*4)+(5*1)+(4*0)+(3*9)+(2*6)+(1*2)=70
70 % 10 = 0
So 4109-62-0 is a valid CAS Registry Number.

4109-62-0Downstream Products

4109-62-0Relevant academic research and scientific papers

Photocyclisation of Enamides. Part 27. Total Syntheses of(+/-)-Yohimbine, (+/-)-Alloyohimbine, and (+/-)-19,20-Didehydroyohimbines

Naito, Takeaki,Hirata, Yumico,Miyata, Okiko,Ninomiya, Ichiya

, p. 2219 - 2226 (2007/10/02)

Total syntheses of five indole alkaloids, (+/-)-yohimbine (10), (+/-)-alloyohimbine (11), and three (+/-)-19,20-didehydroyohimbines (15a, b, and c) (for the first time) were completed from a single common key intermediate (4) via a route involving the ste

Genaral Strategies for the Synthesis of Indole Alkaloids. Total Syntheses of (+/-)-Reserpine and (+/-)-α-Yohimbine

Martin, Stephen F.,Rueeger, Heinrich,Williamson, Sidney A.,Grzejszczak, Slawomir

, p. 6124 - 6134 (2007/10/02)

The concise, total syntheses of the indole alkaloids (+/-)-reserpine (1) and (+/-)-α-yohimbine (4) have been completed by the application of a general strategy that features an intramolecular Diels-Alder reaction for the facile construction of the functio

TOTAL SYNTHESIS OF α-YOHIMBINE

Martin, Stephen F.,Rueeger, Heinrich

, p. 5227 - 5230 (2007/10/02)

A facile total synthesis of the indole alkaloid α-yohimbine (1) from the hydroisoquinoline derivative 5 has been completed.

TOTAL SYNTHESIS OF (+/-)-19,20-DEHYDROYOHIMBINES

Miyata, Okiko,Hirata, Yumiko,Naito, Takeaki,Ninomiya, Ichiya

, p. 2719 - 2722 (2007/10/02)

The first total synthesis of three (+/-)-19,20-dehydroyohimbines (4), (5), and (6) was achieved according to the route involving regioselective acylation of 18,19-dehydroalloyohimbone (1) followed by selective migration of a double bond from the conjugated position to the unconjugated 19-20 position.

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