41104-56-7

Basic information

• Product Name: PHENYL 4-(AMINOSULFONYL)PHENYLCARBAMATE
• Synonyms: PHENYL 4-(AMINOSULFONYL)PHENYLCARBAMATE
• CAS NO: 41104-56-7
• Molecular Formula: C₁₃H₁₂N₂O₄S
• Molecular Weight: 292.31
• Mol File: 41104-56-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PHENYL 4-(AMINOSULFONYL)PHENYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYL 4-(AMINOSULFONYL)PHENYLCARBAMATE(41104-56-7)
• EPA Substance Registry System: PHENYL 4-(AMINOSULFONYL)PHENYLCARBAMATE(41104-56-7)

Safety Data

• Hazardous Substances Data: 41104-56-7(Hazardous Substances Data)

Upstream product

• 63-74-1 sulfanilamide 
• 1885-14-9 phenyl chloroformate 

Relevant articles and documents

Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity

Abstract By using SLC-0111 (4-fluorophenylureido-benzenesulfonamide), a sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor in Phase I clinical trials as an antitumor agent as lead molecule, a series of benzenesulfonamide derivatives incorporating u

Benzylaminoethylureido-Tailed Benzenesulfonamides Show Potent Inhibitory Activity against Bacterial Carbonic Anhydrases

A series of benzylaminoethylureido-tailed benzenesulfonamides was analyzed for their inhibition potential against bacterial carbonic anhydrases (CAs) such as VhCA α, β, and γ from Vibrio cholerae, and BpsCA β and γ-CAs from Burkholderia pseudomallei. Grow

Discovery of 4-piperazinyl-2-aminopyrimidine derivatives as dual inhibitors of JAK2 and FLT3

Hybridization strategy is an effective strategy to obtain multi-target inhibitors in drug design. In this study, we assembled the pharmacophores of momelotinib and tandutinib to get a series of 4-piperazinyl-2-aminopyrimidine derivatives. All compounds were tested for the inhibition of JAK2 and FLT3 enzymes, of which, compounds with potent enzyme activities were assayed for antiproliferative activities against three cancer cell lines (HEL, MV4-11, and HL60). The structure-activity relationship studies were conducted through variations in two regions, the “A” phenyl ring and “B” phenyl ring. Compound 14j showed the most balanced in vitro inhibitory activity against JAK2 and FLT3 (JAK2 IC50 = 27 nM, FLT3 IC50 = 30 nM), and it also showed potent inhibition against the above tested cell lines. In the cellular context, 14j strongly induced apoptosis by arresting cell cycle in the G1/S phase, and was selected as a promising JAK2/FLT3 dual inhibitor.