41106-08-5Relevant academic research and scientific papers
Synthesis of isomeric 2,3,5-trisubstituted perhydropyrrolo[3,4-d]- isoxazole-4,6-diones via 1,3-dipolar cycloaddition reactions
Oezkan, Hamdi,Yildirir, Yilmaz
, p. 954 - 959 (2010)
(Chemical Equation Presented) A series of isoxazolidine derivates (isomeric 2,3,5-trisubstitutedperhydropyrrolo[3,4-d]isoxazole-4,6-diones) used as anti-inflammatory, immunosuppressive, antibacterial agent, and inhibitor for some enzymes were synthesized. These compounds were prepared by 1,3-dipolar cycloaddition of N-methyl maleimide and N-phenyl maleimide with nitrones. Diastereomeric products obtained in this reaction were separated by column chromatography and recrystallized. All compounds synthesized were characterized by elemental analysis and spectroscopic methods (1H NMR, 13C NMR, and FTIR).
