4111-55-1

Usage

Uses

Used in Pharmaceutical Industry:
LITHIUM DICYCLOHEXYLAMIDE is used as a reagent for the synthesis of 2-Dihalo-ribolactones, which are essential synthons for antiviral nucleosides. The application reason is to facilitate the development of antiviral medications that can help combat viral infections and diseases.
In the context of the provided materials, LITHIUM DICYCLOHEXYLAMIDE plays a significant role in the preparation of 2-Dihalo-ribolactones through coupling reactions. This process is vital for the creation of antiviral nucleosides, which are essential components in the formulation of antiviral drugs. By using LITHIUM DICYCLOHEXYLAMIDE in this process, researchers and pharmaceutical companies can develop more effective antiviral medications to address the growing need for treatments against various viral diseases.

InChI:InChI=1/C12H22N.Li/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;/h11-12H,1-10H2;/q-1;+1

Upstream product

• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 917-54-4 methyllithium 
• 17789-14-9 3-(1,3-dioxolan-2-yl)-phenylbromide 
• 110426-35-2 C₂₁H₂₇Li 
• 68695-92-1 (4,4'-Dimethyldiphenylmethyl)lithium 
• 881-42-5 diphenylmethyllithium 

Downstream Products

• 881-42-5 diphenylmethyllithium 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 110426-35-2 C₂₁H₂₇Li 
• 68695-92-1 (4,4'-Dimethyldiphenylmethyl)lithium 
• 76958-90-2 tetracyclohexyl-urea 
• 110-89-4 piperidine 
• 4706-32-5 2-oxo-2-(piperidin-1-yl)acetaldehyde 
• 7560-83-0 N-Methyldicyclohexylamine 
• 110-91-8 morpholine 
• 16423-59-9 2-(morpholin-4-yl)-2-oxoacetaldehyde 
• 111-92-2 dibutylamine 

Relevant academic research and scientific papers

Synthesis of trisubstituted alkenylstannanes through copper-catalyzed three-component coupling of alkylboranes, alkynoates, and tributyltin methoxide

A versatile route to trisubstituted alkenylstannanes is presented. The alkyl and Sn moieties were introduced at the β and α carbon atoms of alkynoates, respectively, in a formal syn addition mode with complete regioselectivity (see scheme). A variety of functional groups were tolerated in the alkylboranes and alkynoates. Copyright

Lithium Dicyclohexylamide in Transition-Metal-Free Fischer-Tropsch Chemistry

Lithium dicyclohexylamide (Cy2NLi) reacts with syn-gas or CO to generate transient intermediates with carbene character, which are capable of reacting further with CO or H2, effecting sequential C-C and C-H bond formations from CO or H2, thus providing a transition-metal-free avenue to the fundamental reactions of the Fischer-Tropsch process. Further experimental and computational data indicate that reactions with CO and H2 are thermodynamically accessible, with a kinetic bias toward CO homologation.

An organocatalytic asymmetric nazarov cyclization

An organocatalytic asymmetric Nazarov cyclization of diketoesters that proceeds by means of a dual activation mechanism has been developed. Screening of a number of catalysts led to a new thiourea that incorporates a primary amino group. The method gives rise to cyclic products with two adjacent quaternary asymmetric carbon atoms, one of which is an all-carbon stereocenter, with complete or nearly complete diastereoselectivity and in high or very high enantiomeric excess. A brief and very convenient synthesis of the acyclic diketoester starting materials through nucleophilic addition to a ketene is also described.

Synthesis of (2-arylethylidene)cyclobutanes by palladium-catalyzed reactions of aryl halides with homoallyl alcohols bearing a trimethylene group at the allylic position

Treatment of aryl bromides with homoallyl alcohols bearing a trimethylene group at the allylic position in the presence of cesium carbonate under palladium catalysis affords (2-arylethylidene) cyclobutanes selectively. The selective formation of the alkylidenecyclobutane skeleton results from regiospecific retroallylation of the homoallyl alcohols, which accompanies the transposition of the double bonds. Georg Thieme Verlag Stuttgart.

AMINOBENZYL-SUBSTITUTED CYCLIC SULFONES USEFUL AS BACE INHIBITORS

The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

TRIAZOLE DERIVATIVE OR SALT THEREOF

[Problem] To provide a compound which may be used in treating diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, especially diabetes and insulin resistance. [Means for Solution] It was found that a triazole derivative or a pharmaceutically acceptable salt thereof, in which the 3-position of triazole ring is substituted with a trisubstituted methyl group and the 5-position is substituted with a lower alkyl, cycloalkyl or the like, has a strong 11β-HSD1-inhibitory activity. In addition, since the triazole derivative of the present invention shows excellent blood glucose-lowering action, it may be used in the treatment of diabetes and insulin resistance.

BESTIMMUNG DER IONENPAAR-BASIZITAT VON LITHIUM- UND KALIUMAMIDEN

Ion pair basicities of lithio and potassio salts of some secondary amines were determined by equilibration with benzyl compounds.With these bases it is possible to span a range of about 19 pK-units from pK = 27 up to 46.The structural dependence of thermodynamic as well as kinetic basicity is discussed.Some new effective amide bases for preparative purposes are recommended.For the first time the pK-value of toluene has been determined by direct equilibration.It amounts to 40.7 in tetrahydrofuran.

Decomposition of the Product of Methoxypalladation of Dichloro(2,2-dimethylbut-3-enyl methyl sulphide)palladium(II). Identification of an α-Alkoxyalkylpalladium(II) Intermediate

The methoxypalladation product >2> from the title complex (3) undergoes relatively slow decomposition in solution via at least two pathways.The major pathway leads to complexes containing the acetal MeSCH2CMe2CH2CH(OMe)2 or the corresponding aldehyde.An important intermediate in this pathway is the α-methoxyalkylpalladium(II) derivative>2> which has also been generated by reaction of MeSCH2CMe2CH2CH(Cl)OMe with bis(dibenzylideneacetone)palladium(0).The minor pathway involves hydride transfer between ligand molecules and leads to complexes containing both oxidised and reduced ligands.More efficient hydride transfer is observed when the product >2> from reaction of (3) with HgPh2 is treated with MeSCH2CMe2CH=CH2.