411208-45-2Relevant academic research and scientific papers
Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands
Vercouillie, Johnny,Mavel, Sylvie,Galineau, Laurent,Ragusa, Tiziana,Innis, Robert,Kassiou, Michael,Chalon, Sylvie,Dolle, Frederic,Besnard, Jean-Claude,Guilloteau, Denis,Emond, Patrick
, p. 1297 - 1300 (2007/10/03)
As the serotonin transporter (SERT) is involved in several neurodegenerative and psychiatric disorders, radiopharmaceuticals to image the SERT by PET or SPECT would be very valuable in studying these diseases. For the development of imaging agents, we hav
Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2′-amino-4′-substituted-phenylthio)benzylamines: Potential candidates as selective serotonin transporter radioligands
Jarkas, Nachwa,McConathy, Jonathan,Voll, Ronald J.,Goodman, Mark M.
, p. 4254 - 4265 (2007/10/03)
A series of N,N-dimethylated and N-monomethylated analogues of N,N-dimethyl-2-(2′-amino-4′-iodophenylthio)benzylamine substituted at the 4′-phenyl position have been prepared and evaluated in vitro for serotonin transporter (SERT) selectivity. Several der
Fluorinated diaryl sulfides as serotonin transporter ligands: Synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents
Huang, Yiyun,Bae, Sung-A,Zhu, Zhihong,Guo, Ningning,Roth, Bryan L.,Laruelle, Marc
, p. 2559 - 2570 (2007/10/03)
A series of new, fluorine-containing substituted diphenyl sulfides was synthesized to serve as candidate ligands for positron emission tomography (PET) imaging of the serotonin transporter (SERT) and to further probe the structure-activity relationship (S
Substituted diphenyl sulfides as selective serotonin transporter ligands: Synthesis and in vitro evaluation
Emond, Patrick,Vercouillie, Johnny,Innis, Robert,Chalon, Sylvie,Mavel, Sylvie,Frangin, Yves,Halldin, Christer,Besnard, Jean-Claude,Guilloteau, Denis
, p. 1253 - 1258 (2007/10/03)
A series of diphenyl sulfide derivatives substituted at the 1-, 2′-, and 4′-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (SERT), and norepinephrine transporters. The examination of Ki val
Carbon-11 labelling of MADAM in two different positions: a highly selective PET radioligand for the serotonin transporter
Tarkiainen, Jari,Vercouillie, Johnny,Emond, Patrick,Sandell, Johan,Hiltunen, Jukka,Frangin, Yves,Guilloteau, Denis,Halldin, Christer
, p. 1013 - 1024 (2007/10/03)
Imaging by scintigraphy the serotonin transporter (5-HTT) in the living human brain would be of great value in research on the pathophysiology and treatment of neuropsychiatric disorders such as depression. For that reason, and in order to obtain a select
