411233-94-8

Upstream product

• 15226-74-1 dicobalt octacarbonyl 
• 2071-20-7 bis-diphenylphosphinomethane 

Downstream Products

• 247037-17-8 Co2(μ-η(2),η(2):μ-η(2),η(2)-Me3SiCCCCCCSiMe3)(CO4)(dppm) 
• 247037-17-8 Co2(μ-η(2),η(2)-Me2SiC2CCCCSiMe3)(CO)4(dppm) 
• 247232-98-0 C₆H₅C₂Co₂(CO)4((C₆H₅)2PCH₂P(C₆H₅)2)C₁₀H₆(CCC₆H₅) 
• 247232-72-0 (C₅H₅)2Fe₂(C₅H₄)2(C₁₄H₆O) 
• 247232-70-8 (C₅H₅)2Fe₂(C₅H₄)2(C₁₅H₆O) 
• 411233-96-0 [(μ-P,P-bis(diphenylphosphino)methylene)Co2(CO)4(μ-bis(diphenylphosphino)acetylene)] 
• 411233-97-1 [(μ-P,P-bis(diphenylphosphino)methylene)Co2(CO)4(μ-PPh2CCP(O)Ph2)] 
• 411233-98-2 [(μ-P,P-bis(diphenylphosphino)methylene)Co2(CO)4(μ-P(O)Ph2CCP(O)Ph2)] 
• 795306-41-1 [(bis(diphenylphosphino)methane)Co2(CO)4(μ-4-ethynylaniline)] 

Relevant academic research and scientific papers

Organometallic Nucleosides: Synthesis and Biological Evaluation of Substituted Dicobalt Hexacarbonyl 2′-Deoxy-5-oxopropynyluridines

Reactions of dicobalt octacarbonyl [Co2(CO)8] with 2′-deoxy-5-oxopropynyluridines and related compounds gave dicobalt hexacarbonyl nucleoside complexes (83–31 %). The synthetic outcomes were confirmed by X-ray structure determination of dicobalt hexacarbonyl 2′-deoxy-5-(4-hydroxybut-1-yn-1-yl)uridine, which exhibits intermolecular hydrogen bonding between a modified base and ribose. The electronic structure of this compound was characterized by the DFT calculations. The growth inhibition of HeLa and K562 cancer cell lines by organometallic nucleosides was examined and compared to that by alkynyl nucleoside precursors. Coordination of the dicobalt carbonyl moiety to the 2′-deoxy-5-alkynyluridines led to a significant increase in the cytotoxic potency. The cobalt compounds displayed antiproliferative activities with median inhibitory values (IC50) in the range of 20 to 80 μm for the HeLa cell line and 18 to 30 μm for the K562 cell line. Coordination of an acetyl-substituted cobalt nucleoside was expanded by using the 1,1-bis(diphenylphosphino)methane (dppm) ligand, which exhibited cytotoxicity at comparable levels. The formation of reactive oxygen species in the presence of cobalt compounds was determined in K562 cells. The results indicate that the mechanism of action for most antiproliferative cobalt compounds may be related to the induction of oxidative stress.

Structure of Co2(CO)6(dppm) and Co2(CO)5(CHCO2Et)(dppm) (dppm = Ph2PCH2PPh2) and exchange reaction with 13CO: An experimental and computational study

Crystal structures of Co2(CO)6(dppm) (1) and Co2(CO)5(CHCO2Et)(dppm) (2) (dppm = Ph2PCH2PPh2) show asymmetry with respect to the orientation of the phenyl groups in 1

Bis(diphenylphosphino) acetylene as bifunctional ligand in dicobalt carbonyl complexes

Treatment of bis(diphenylphosphino)acetylene (DPPA) with a bis(diphenylphosphino)-methylene (DPPM)-bridged dicobalt complex, [{μ-P,P-PPh2CH2PPh2}Co2(CO)6 ], 3, yielded a DPPA-bridged dicobalt compound