411235-57-9

Basic information

• Product Name: Cyclopropylboronic acid
• Synonyms: AKOS BRN-0457;CYCLOPROPYLBORONIC ACID;Cyclopropylboronic acid,monohydrate ;CYCLOROPYLBORONIC ACID;Boronic acid, cyclopropyl- (9CI);Cyclopropylboronic;Cyclopropylboronic acid 95%;Chemical Name: Cyclopropylboronic acid
• CAS NO: 411235-57-9
• Molecular Formula: C₃H₇BO₂
• Molecular Weight: 85.9
• EINECS: 1592732-453-0
• Product Categories: BORONICACID;blocks;BoronicAcids;Boronic Acids & Esters;Cyclopropyl;Organoborons;Boronic acid;CHIRAL CHEMICALS;Boronic Acids & Esters;Ring Systems;Alkyl;Boronic Acids;Boronic Acids and Derivatives;Alkyl Boronic Acids;Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Organometallic Reagents
• Mol File: 411235-57-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 90-95 °C(lit.)
• Boiling Point: 205.1 °C at 760 mmHg
• Flash Point: 77.9 °C
• Appearance: white/Powder
• Density: 1.11 g/cm³
• Vapor Pressure: 0.0606mmHg at 25°C
• Refractive Index: 1.442
• Storage Temp.: Store below -20
• Solubility: DMSO
• PKA: 10.49±0.20(Predicted)
• Sensitive: moisture sensitive
• CAS DataBase Reference: Cyclopropylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropylboronic acid(411235-57-9)
• EPA Substance Registry System: Cyclopropylboronic acid(411235-57-9)

Safety Data

• Hazard Codes: Xn,T
• Statements: 22-36-61-60-36/37/38
• Safety Statements: 26-36-45-53-37/39
• WGK Germany: 3
• TSCA: No
• HazardClass: IRRITANT, IRRITANT-HARMFUL
• Hazardous Substances Data: 411235-57-9(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

Different sources of media describe the Uses of 411235-57-9 differently. You can refer to the following data:
1. Cyclopropylboronic Acid is an organoboronic acid commonly used in highly efficient Suzuki coupling reactions.
2. Reagent used for? ;Microwave-assisted copper(II)-catalyzed N-cyclopropylation1? ;Nickel- and copper-catalyzed Suzuki-Miyaura coupling reaction of arenes2? ;Palladacycle-catalyzed Suzuki-cross coupling of aryl halides with cyclopropylboronic acid3? ;Palladium(0)-catalyzed cyclopropane C-H bond functionalization4? ;Palladium-catalyzed decarboxylative coupling5? ;Palladium-catalyzed ligand-directed oxidative functionalization of cyclopropanes6? ;Palladium-catalyzed Suzuki coupling reaction7Reagent used in Preparation of? ;Diaryl ketones by arylation
3. suzuki reaction

InChI:InChI=1/C3H7BO2/c5-4(6)3-1-2-3/h3,5-6H,1-2H2

Synthetic route

ethene (74-85-1) + formyl boronic acid + 3,5-dinitro-p-toluenesulfonylhydrazide → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
Stage #1: formyl boronic acid; 3,5-dinitro-p-toluenesulfonylhydrazide In methanol Reflux; Stage #2: With n-butyllithium In tetrahydrofuran at 0℃; for 0.5h; Stage #3: ethene Reagent/catalyst; Solvent; Further stages;	92%

diazomethane (186581-53-3, 908094-01-9) + pinacol vinylboronate (75927-49-0) → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
Stage #1: diazomethane; pinacol vinylboronate With palladium diacetate In tert-butyl methyl ether Inert atmosphere; Stage #2: With sodium periodate In tetrahydrofuran; water at 20℃; for 0.05h; Reagent/catalyst; Temperature;	86%

diiodomethane (75-11-6) + pinacol vinylboronate (75927-49-0) → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
Stage #1: diiodomethane; pinacol vinylboronate With diethylzinc at 60℃; for 12h; Inert atmosphere; Stage #2: With 2,2'-iminobis[ethanol] at 55℃; for 4h; Solvent; Temperature; Reagent/catalyst;	82%

tricyclopropylboroxin → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
In water at 20℃; for 1h; Reagent/catalyst;	77%

cyclopropylmagnesium bromide (23719-80-4) → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
Stage #1: cyclopropylmagnesium bromide With Trimethyl borate In tetrahydrofuran at -78 - 20℃; for 7h; Stage #2: With hydrogenchloride for 1h;	56%

cyclopropylboronic acid methyliminodiacetic acid ester (1104637-36-6) → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 23℃; for 0.333333h;	53%

Trimethyl borate (121-43-7) + cyclopropylmagnesium bromide (23719-80-4) → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
Stage #1: Trimethyl borate; cyclopropylmagnesium bromide In tetrahydrofuran at -78 - 20℃; Stage #2: With hydrogenchloride In tetrahydrofuran; water	27%

C5H11BO2 (1404118-58-6) → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
With hydrogenchloride; water for 1h;

cyclopropylboronic acid methyliminodiacetic acid ester (1104637-36-6) + water (7732-18-5) → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
In not given hydrolysis of appropriate N-methyliminodiacetic acid boronate;

potassium cyclopropyltrifluoroborate (1065010-87-8) + water (7732-18-5) → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
With glass or DBU or Cs2CO3 In tetrahydrofuran; water Kinetics; hydrolysis at 55°C in THF/H2O in the presence of glass powder or DBU or Cs2CO3; not isolated;

potassium cyclopropyltrifluoroborate (1065010-87-8) → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
With water In tetrahydrofuran at 55℃; Kinetics; Reagent/catalyst;

cyclopropylboronic acid pinacol ester (126689-01-8) + water (7732-18-5) → cyclopropylboronic acid (411235-57-9)

Conditions	Yield
Stage #1: cyclopropylboronic acid pinacol ester; water With sodium periodate In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Sealed tube; Stage #2: With hydrogenchloride In tetrahydrofuran; water at 20℃; for 18h; Inert atmosphere; Sealed tube;

phthalimide (136918-14-4) + cyclopropylboronic acid (411235-57-9) → 2-cyclopropylisoindoline-1,3-dione (38939-62-7)

Conditions	Yield
With 1,1'-bipyridyl; copper diacetate; sodium carbonate In 1,2-dichloro-ethane at 70℃;	100%
With pyridine; 2-(2-imidazolinyl)phenol; copper diacetate In toluene at 95℃; for 48h;	83%

(+/-)-tert-butyl 4-((1-(5-bromo-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-7-yl)ethoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate (1100213-76-0) + cyclopropylboronic acid (411235-57-9) → (+/-)-tert-butyl 4-((1-(5-cyclopropyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-7-yl)ethoxy)methyl)-4-(4-fluorophenyl)piperidine-1-carboxylate (1100213-80-6)

Conditions	Yield
With potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran; water at 100℃; for 1h; Microwaves;	100%

4-Bromo-2-nitroaniline (875-51-4) + cyclopropylboronic acid (411235-57-9) → 4-cyclopropyl-2-nitro-phenylamine (335254-72-3)

Conditions	Yield
With potassium phosphate; palladium diacetate; catacxium A In water; toluene at 90℃; Inert atmosphere;	100%
With potassium phosphate; palladium diacetate; tricyclohexylphosphine In water; toluene at 100℃; for 12h; Inert atmosphere;	89%
With potassium phosphate; palladium diacetate; triphenylphosphine In toluene at 100℃; for 17h; Sealed tube;	72%

3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde (1168720-53-3) + cyclopropylboronic acid (411235-57-9) → 3-cyclopropyl-1-((2-(trimethylsilyI)ethoxy)methyl)-1H-indazole-6-carbaldehyde (1168722-20-0)

Conditions	Yield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; toluene at 95 - 100℃; for 24h; Inert atmosphere;	100%

2-{3-[4-bromo-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-ethanol (1268385-47-2) + cyclopropylboronic acid (411235-57-9) → 2-{3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}ethanol (1268385-48-3)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In water; toluene at 55℃; Inert atmosphere;	100%
With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane at 90℃; for 1h; Inert atmosphere;	100%

4-chloro-3-nitropyridine (13091-23-1) + cyclopropylboronic acid (411235-57-9) → 4-cyclopropyl-3-nitropyridine (1365763-14-9)

Conditions	Yield
With potassium carbonate In xylene at 130℃; Inert atmosphere;	100%
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In xylene at 130℃; Inert atmosphere;	100%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 130℃; Inert atmosphere;	100%
With potassium fluoride; sodium bromide; tetrakis(triphenylphosphine) palladium(0) In toluene Inert atmosphere; Reflux;	63%

ethyl 2-(2-chloro-6-cyclopropylpyridin-4-yl)-3-(2-fluorophenyl)cyclopropanecarboxylate + cyclopropylboronic acid (411235-57-9) → rac-(1S,2R,3R)-ethyl 2-(2,6-dicyclopropylpyridin-4-yl)-3-(2-fluorophenyl)cyclopropanecarboxylate

Conditions	Yield
With potassium phosphate; palladium diacetate; tricyclohexylphosphine In water; toluene at 100℃; for 17h; Inert atmosphere;	100%

tert-butyl 4-((5-chloro-6-isopropoxypyridin-3-yl)oxy)-2-fluoro-5-iodobenzoate (1533431-94-5) + cyclopropylboronic acid (411235-57-9) → tert-butyl 4-((5-chloro-6-isopropoxypyridin-3-yl)oxy)-5-cyclopropyl-2-fluorobenzoate (1533431-95-6)

Conditions	Yield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 150℃; for 0.5h; Inert atmosphere; Microwave irradiation;	100%
With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 150℃; for 0.75h; Inert atmosphere; Microwave irradiation;	50%

methyl 2-bromo-4'-fluoro-5-hydroxybiphenyl-4-carboxylate + cyclopropylboronic acid (411235-57-9) → methyl 2-cyclopropyl-4'-fluoro-5-hydroxybiphenyl-4-carboxylate

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate In water; toluene at 100℃; Suzuki Coupling;	100%
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); sodium carbonate In water; toluene at 100℃; for 1h; Inert atmosphere;	9.65 g

methyl 4-bromo-2-fluorobenzoate (179232-29-2) + cyclopropylboronic acid (411235-57-9) → methyl 4-cyclopropyl-2-fluorobenzoate (1613413-65-2)

Conditions	Yield
With potassium fluoride; tetrakis(triphenylphosphine) palladium(0) In toluene at 150℃; for 2h; Microwave irradiation; Inert atmosphere;	100%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate In tetrahydrofuran; water; toluene at 90℃; for 16h; Inert atmosphere;	100%
With palladium diacetate; tricyclohexylphosphine In water; toluene at 100℃; Inert atmosphere;	99%

cyclopropylboronic acid (411235-57-9) + 4-bromo-1-fluoro-2-methoxy-benzene (103291-07-2) → 4-cyclopropyl-1-fluoro-2-methoxybenzene

Conditions	Yield
With potassium phosphate; palladium diacetate; tricyclohexylphosphine In water; toluene at 100℃; for 3h; Suzuki Coupling; Inert atmosphere;	100%

methyl 4-bromo-3-fluorobenzoate (849758-12-9) + cyclopropylboronic acid (411235-57-9) → C11H11FO2

Conditions	Yield
With potassium fluoride; tetrakis(triphenylphosphine) palladium(0) In toluene at 150℃; for 2h; Microwave irradiation; Inert atmosphere;	100%

4-benzyloxy-2-nitro-chlorobenzene (79035-13-5) + cyclopropylboronic acid (411235-57-9) → 4-(benzyloxy)-1-cyclopropyl-2-nitrobenzene

Conditions	Yield
With tricyclohexylphosphine tetrafluoroborate; palladium diacetate; potassium carbonate In 1,4-dioxane; water at 120℃; for 4h; Inert atmosphere;	100%

ethyl 10'-bromo-9'-(cyclopropylmethoxy)-2'-oxo-2',7'-dihydrospiro[cyclobutane-1,6'-pyrido[2,1-a]isoquinoline]-3'-carboxylate + cyclopropylboronic acid (411235-57-9) → ethyl 10'-cyclopropyl-9'-(cyclopropylmethoxy)-2'-oxo-2',7'dihydrospiro[cyclobutane-1,6'-pyrido[2,1-a]isoquinoline]-3'-carboxylate

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In water; toluene at 85℃;	100%

5-chloro-3-fluoro-pyridine-2-amine (246847-98-3) + cyclopropylboronic acid (411235-57-9) → 5-cyclopropyl-3-fluoropyridin-2-amine

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In water; toluene at 90℃; for 16h;	100%
With palladium diacetate

ethyl 5-bromoindolecarboxylate (16732-70-0) + cyclopropylboronic acid (411235-57-9) → ethyl 5-bromo-1-cyclopropyl-1H-indole-2-carboxylate

Conditions	Yield
With [2,2]bipyridinyl; copper diacetate; sodium carbonate In dichloromethane at 80℃; for 16h; Inert atmosphere;	100%

C17H15BrClFN2O4 + cyclopropylboronic acid (411235-57-9) → C20H20ClFN2O4

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate In water; N,N-dimethyl-formamide at 90℃; Microwave irradiation; Inert atmosphere;	100%

3-bromo-4-fluoroaniline (656-64-4) + cyclopropylboronic acid (411235-57-9) → 3-cyclopropyl-4-fluoro-aniline (890129-90-5)

Conditions	Yield
With potassium phosphate; palladium diacetate; triphenylphosphine In toluene at 100℃; for 16h; Inert atmosphere;	99.35%
With potassium phosphate; palladium diacetate In water; toluene at 100℃; for 16h; Inert atmosphere;	71.2%
With potassium phosphate; tricyclohexylphosphine; palladium diacetate In water; toluene at 100℃;	64%

para-nitrophenyl bromide (586-78-7) + cyclopropylboronic acid (411235-57-9) → 4-nitrophenylcyclopropane (6921-44-4)

Conditions	Yield
With palladium diacetate; potassium carbonate; tricyclohexylphosphine In water; toluene at 80℃; for 1h;	99%
With potassium phosphate tribasic heptahydrate; C45H53ClFeNO2PPd In water; toluene at 100℃; for 8h; Suzuki coupling; Inert atmosphere;	96%
With potassium carbonate; bis(η3-allyl-μ-chloropalladium(II)); cis,cis,cis-1,2,3,4-tetrakis (diphenylphosphinomethyl)cyclopentane In xylene at 130℃; for 20h; Suzuki cross-coupling;	94%

7-chloro-4-methyl-2-bromo-4H-imidazo[4,5-d]thiazolo[5,4-b]-pyridine (805319-85-1) + cyclopropylboronic acid (411235-57-9) → 8-methyl-2-cyclopropyl-5-chloro-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridine (805321-13-5)

Conditions	Yield
With potassium phosphate; water; tricyclohexylphosphine; palladium diacetate In toluene at 100℃; for 2h;	99%

4-bromo-2,3-dihydro-1H-inden-1-one O-methyl oxime (812694-98-7) + cyclopropylboronic acid (411235-57-9) → 4-cyclopropyl-2,3-dihydro-1H-inden-1-one O-methyl oxime (935681-11-1)

Conditions	Yield
With potassium phosphate; palladium diacetate; tricyclohexylphosphine In water; toluene at 100℃; for 3h; Suzuki Coupling;	99%
With potassium phosphate; tricyclohexylphosphine; palladium diacetate In water; toluene at 100℃; for 3h; microwave irradiation;	82%

5-(5-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde (1048018-65-0) + cyclopropylboronic acid (411235-57-9) → 5-(5-cyclopropyl-1H-pyrrolo[2,3-b]pyridin-1-yl)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde (1048019-07-3)

Conditions	Yield
Stage #1: 5-(5-bromo-1H-pyrrolo[2,3-b]pyridin-1-yl)-1,3-dimethyl-1H-pyrazole-4-carbaldehyde; cyclopropylboronic acid With potassium carbonate In toluene at 20℃; for 0.5h; Stage #2: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0) In toluene at 100℃; for 18h;	99%

2-iodo-4-nitrophenylamine (6293-83-0) + cyclopropylboronic acid (411235-57-9) → N-cyclopropyl-2-iodo-4-nitroaniline (1228357-86-5)

Conditions	Yield
With [2,2]bipyridinyl; oxygen; copper diacetate; sodium carbonate In 1,2-dichloro-ethane at 70℃; Chan-Lam reaction;	99%

N-methyl-N-(4-methoxyphenyl)amine (5961-59-1) + cyclopropylboronic acid (411235-57-9) → N-cyclopropyl-N-(4-methoxyphenyl)methylamine

Conditions	Yield
With [2,2]bipyridinyl; oxygen; copper diacetate; sodium carbonate In 1,2-dichloro-ethane at 70℃; for 2h; Chan-Lam reaction;	99%

2-Chloroanisole (766-51-8) + cyclopropylboronic acid (411235-57-9) → 1-cyclopropyl-2-methoxybenzene (10292-66-7)

Conditions	Yield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); rac-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole In toluene at 100℃; for 24h; Suzuki coupling; Inert atmosphere;	99%

cyclopropylboronic acid (411235-57-9) + 2-bromo-6-fluorobenzoic acid methyl ester (820236-81-5) → methyl 2-cyclopropyl-6-fluorobenzoate (1352133-13-1)

Conditions	Yield
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In water; toluene for 2.5h; Suzuki Coupling; Inert atmosphere; Reflux;	99%
With potassium phosphate; tetrakis(triphenylphosphine) palladium(0) In water; toluene for 2.5h; Inert atmosphere; Reflux;	99%

ethyl-2-(4-chlorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate (1331943-19-1) + cyclopropylboronic acid (411235-57-9) → ethyl 2-(4-chlorophenyl)-5-cyclopropyl-6-nitrobenzofuran-3-carboxylate (1331943-20-4)

Conditions	Yield
With potassium fluoride; sodium bromide; tetrakis(triphenylphosphine) palladium(0) In water; toluene for 20h; Inert atmosphere; Reflux;	99%
With potassium fluoride; tetrakis(triphenylphosphine) palladium(0); sodium bromide In water; toluene for 20h; Inert atmosphere; Reflux;	7.9 g

2-Amino-4-chloropyridine (19798-80-2) + cyclopropylboronic acid (411235-57-9) → 2-amino-4-(cyclopropyl)pyridine (908269-97-6)

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; tricyclohexylphosphine In 1,4-dioxane; acetonitrile at 120℃; Inert atmosphere;	99%
With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane; water at 80℃; for 15h;

7-bromo-8-methoxyquinaldine (1412255-28-7) + cyclopropylboronic acid (411235-57-9) → 7-cyclopropyl-8-methoxy-2-methylquinoline (1412255-31-2)

Conditions	Yield
With tricyclohexylphosphine; palladium diacetate In water; toluene at 100℃; for 6h;	99%

2-{[4-(2-oxo-1,3-oxazolidin-3-yl)-1-peridinyl]carbonyl}-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-5-yl trifluoromethanesulfonate (1297136-93-6) + cyclopropylboronic acid (411235-57-9) → 3-(1-{[5-cyclopropyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-2-yl]carbonyl}-4-piperidinyl)-1,3-oxazolidin-2-one (1297136-92-5)

Conditions	Yield
With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane at 90℃; for 3h; Inert atmosphere;	99%

Upstream product

• 23719-80-4 cyclopropylmagnesium bromide 
• 121-43-7 Trimethyl borate 
• 1404118-58-6 C₅H₁₁BO₂ 
• 1104637-36-6 cyclopropylboronic acid methyliminodiacetic acid ester 
• 7732-18-5 water 
• 1065010-87-8 potassium cyclopropyltrifluoroborate 
• 126689-01-8 cyclopropylboronic acid pinacol ester 
• 4333-56-6 cyclopropyl bromide 
• 186581-53-3 diazomethane 
• 75927-49-0 pinacol vinylboronate 
• 75-11-6 diiodomethane 
• 74-85-1 ethene 

Downstream Products

• 20797-87-9 2-cyclopropyl pyridine 
• 366-18-7 [2,2]bipyridinyl 
• 188918-72-1 3-cyclopropylpyridine 
• 873-49-4 cyclopropylbenzene 
• 54134-93-9 1-cyclopropyl-3-methoxybenzene 
• 42801-87-6 2-nitro-1,4-dicyclopropylbenzene 
• 1126-27-8 1-cyclopropyl-4-benzonitrile 
• 20034-50-8 4-cyclopropylbenzaldehyde 
• 485402-64-0 3-cyclopropylaniline 
• 39763-81-0 5-cyclopropyl-furan-2-carbaldehyde 
• 6921-44-4 4-nitrophenylcyclopropane 
• 691857-52-0 ethyl 5-cyclopropyl-2-(4-fluorophenyl)-6-nitrobenzofuran-3-carboxylate 
• 888499-96-5 C₁₁H₁₃NO₃ 
• 885133-27-7 1-cyclopropyl-3-ethyl-6-{1-[4-(methylsulfonyl)phenyl]-1H-pyrazol-5-yl}-1H-indazole 

Relevant articles and documents

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Synthesis method of cyclopropyl boric acid

The invention discloses a synthesis method of cyclopropyl boric acid, and belongs to the field of boric acid synthesis in organic chemistry. The synthesis method comprises the following steps: starting from formyl boric acid, enabling the formyl boric acid with strong electron-withdrawing sulfohydrazide to generate hydrazone, then introducing ethylene under the catalysis of ferriporphyrin, and reacting, thus obtaining the cyclopropyl boric acid. The synthesis method disclosed by the invention is simple in operation, the use of cyclopropyl bromide in a traditional technological method is avoided by adopting cyclopropanation reaction under metal catalysis, and a new synthesis path is provided for synthesis of the cyclopropyl boric acid.

A process for the preparation method of the cyclopropyl-boronic acid

The invention discloses a method for preparing cyclopropyl boronic acid. Cyclopropyl methanoic acid is adopted as a raw material and added into a solution obtained after n-butyllithium reacts with organic alkali at the low temperature, and then a boronizing reagent is added into the mixture; after boronation is finished, acid is added for quenching to obtain 1-carboxyl cyclopropyl boronic acid; the intermediate is added into high-boiling-point solvent and heated until the temperature is 80 DEG C-150 DEG C, after reaction deacidification, methylbenzene is added into the mixed solution for dehydration to form cyclopropyl boronic acid trimer, and the cyclopropyl boronic acid trimer is hydrolyzed to obtain the cyclopropyl boronic acid; the melting point of the obtained cyclopropyl boronic acid is 90 DEG C-95 DEG C, and the HNMR purity of the obtained cyclopropyl boronic acid is over 98%. The method is easy to operate and suitable for industrial scale-up production, and no highly toxic chemical is used in the whole process.